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PEX5 and CCDC14
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PEX5
CCDC14
Description
peroxisomal biogenesis factor 5
coiled-coil domain containing 14
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Peroxisome
Peroxisomal Membrane
Peroxisomal Matrix
Golgi Apparatus
Cytosol
Membrane
Protein-containing Complex
Cytoplasm
Centrosome
Cytoskeleton
Cilium
Microtubule Cytoskeleton
Centriolar Satellite
Ciliary Basal Body
Molecular Function
Peroxisome Targeting Sequence Binding
Peroxisome Matrix Targeting Signal-1 Binding
Protein Binding
Enzyme Binding
Small GTPase Binding
Peroxisome Membrane Targeting Sequence Binding
Protein Carrier Chaperone
Protein Binding
Biological Process
Very Long-chain Fatty Acid Metabolic Process
Pexophagy
Neuron Migration
Protein Monoubiquitination
Protein Targeting To Peroxisome
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Mitochondrion Organization
Mitochondrial Membrane Organization
Endoplasmic Reticulum Organization
Peroxisome Organization
Protein Transport
Protein Import Into Peroxisome Matrix
Protein Import Into Peroxisome Matrix, Docking
Protein Import Into Peroxisome Matrix, Translocation
Protein Import Into Peroxisome Matrix, Receptor Recycling
Cerebral Cortex Cell Migration
Cerebral Cortex Neuron Differentiation
Negative Regulation Of Protein-containing Complex Assembly
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Multicellular Organism Growth
Protein Unfolding
Protein Import Into Peroxisome Matrix, Substrate Release
Protein Import Into Peroxisome Membrane
Cell Development
Neuromuscular Process
Protein Tetramerization
Substantia Nigra Development
Protein Localization To Centrosome
Pathways
Pexophagy
Drugs
Diseases
Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
IgG glycosylation (
23382691
)
Night sleep phenotypes (
27126917
)
Refractive error (
32231278
)
Intelligence (MTAG) (
29326435
)
Interacting Genes
77 interacting genes:
ACD
ACOT2
ACOT4
ACOT8
ACOX2
ACOX3
AGXT
AMACR
ANKRD50
ATM
BAAT
BRCA1
CAPRIN2
CCDC14
CROT
DAO
DDO
DECR2
DHRS4
ECI2
EP400P1
EPHX2
GDPD5
GLMN
GNPAT
GSTK1
HACL1
HAO1
HAO2
HMGCL
HNRNPH1
HOXA7
HSPA1A
IDE
IDH1
LDHB
LONP2
MKRN3
MLYCD
MPV17
NOS2
NUDT19
NUDT3
NUDT7
NUFIP2
PAOX
PDZK1
PEX1
PEX10
PEX12
PEX13
PEX14
PEX26
PEX6
PEX7
PIPOX
POT1
PRDX5
PRR13
PSAP
RPL14
S100A6
SCARB1
SCP2
SCRN2
SIRT3
SLC27A2
SNUPN
SSTR5
TIMMDC1
TINF2
TM6SF1
TOMM7
USP2
USP9X
ZFAND3
ZNF772
17 interacting genes:
APP
CALM1
CEP63
CSNK1D
CSNK1E
DDX6
KDM1A
MAGEA11
MAGEB4
MAPK14
PEX5
PIK3R3
PLAC9
PNKP
RNF8
TXLNB
UBQLN4
Entrez ID
5830
64770
HPRD ID
02684
07801
Ensembl ID
ENSG00000139197
ENSG00000175455
Uniprot IDs
A0A0S2Z480
A0A0S2Z4F3
A0A0S2Z4H1
B4DR50
B4E0T2
P50542
J3QT39
Q49A88
PDB IDs
1FCH
2C0L
2C0M
2J9Q
2W84
3R9A
4BXU
4KXK
4KYO
7Z0K
9GAG
Enriched GO Terms of Interacting Partners
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Peroxisome
Peroxisomal Matrix
Carboxylic Acid Catabolic Process
Establishment Of Protein Localization To Peroxisome
Protein Import Into Peroxisome Matrix
Fatty Acid Oxidation
Carboxylic Acid Metabolic Process
Fatty Acid Catabolic Process
Organic Acid Metabolic Process
Lipid Oxidation
Peroxisome Organization
Fatty Acid Metabolic Process
Monocarboxylic Acid Metabolic Process
Peroxisomal Membrane Transport
Peroxisomal Membrane
Lipid Modification
Protein Import Into Peroxisome Matrix, Receptor Recycling
Intracellular Protein Transmembrane Transport
Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Small Molecule Metabolic Process
Lipid Metabolic Process
Protein Unfolding
Lipid Catabolic Process
Protein Transmembrane Transport
Catabolic Process
Fatty Acid Beta-oxidation
Receptor Recycling
Protein Targeting To Peroxisome
Cytosol
Establishment Of Protein Localization To Organelle
Receptor Metabolic Process
Sulfur Compound Metabolic Process
Acyl-CoA Metabolic Process
Bile Acid Biosynthetic Process
Carboxylic Acid Biosynthetic Process
Protein Import Into Peroxisome Matrix, Substrate Release
Bile Acid Metabolic Process
Fatty Acid Alpha-oxidation
Oxidoreductase Activity
Protein Localization To Organelle
Purine-containing Compound Metabolic Process
Small Molecule Biosynthetic Process
Peroxisomal Importomer Complex
Malonyl-CoA Catabolic Process
Protein Transmembrane Transporter Activity
Nucleoside Phosphate Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Protein Import Into Peroxisome Matrix, Translocation
Telomere Assembly
Organophosphate Metabolic Process
Regulation Of Double-strand Break Repair
Regulation Of Canonical Wnt Signaling Pathway
Response To Radiation
DNA Damage Response
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of DNA Repair
Regulation Of Cellular Response To Stress
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Neuron Maturation
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Spindle Pole
Cellular Response To Stress
Response To Ionizing Radiation
Signal Transduction In Response To DNA Damage
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Non-canonical Wnt Signaling Pathway
Regulation Of DNA Recombination
DNA Repair-dependent Chromatin Remodeling
Negative Regulation Of Metabolic Process
Enzyme Binding
Regulation Of Metabolic Process
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein-containing Complex
Positive Regulation Of Proteolysis
Amyloid-beta Complex
Growth Cone Lamellipodium
Protein Metabolic Process
Regulation Of Response To Calcium Ion
Response To Nerve Growth Factor
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Endocytosis
Cytosol
Cellular Response To Nerve Growth Factor Stimulus
Spindle Microtubule
Regulation Of Proteasomal Protein Catabolic Process
Concave Side Of Sperm Head
Positive Regulation Of Protein Catabolic Process
Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of DNA Metabolic Process
Cellular Response To CAMP
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