PEX5 and RPL14

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		PEX5	RPL14
Name		peroxisomal biogenesis factor 5	ribosomal protein L14
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein-containing Complex	Cytoplasm Cytosol Ribosome Postsynaptic Density Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein Carrier Chaperone	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Pexophagy Neuron Migration Protein Monoubiquitination Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Beta-oxidation Mitochondrion Organization Mitochondrial Membrane Organization Endoplasmic Reticulum Organization Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Cerebral Cortex Cell Migration Cerebral Cortex Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Reactive Oxygen Species Positive Regulation Of Multicellular Organism Growth Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Cell Development Neuromuscular Process Protein Tetramerization	Cytoplasmic Translation RRNA Processing Translation Ribosomal Large Subunit Biogenesis
Pathways		Pexophagy	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		None	Artenimol
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	None
GWAS		IgG glycosylation ( 23382691 ) Night sleep phenotypes ( 27126917 ) Refractive error ( 32231278 )	Neuroticism ( 29255261 )
Interacting Genes		77 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 NUFIP2 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772	8 interacting genes: ALG13 FBXO7 KCNK4 KLF10 PEX5 PHLDA1 PTEN TLE6
Entrez ID		5830	9045
HPRD ID		02684	10617
Ensembl ID		ENSG00000139197	ENSG00000188846
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	P50914
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO 7Z0K 9GAG	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
GO Terms Enriched among Interactors		Peroxisome Peroxisomal Matrix Carboxylic Acid Catabolic Process Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Carboxylic Acid Metabolic Process Fatty Acid Catabolic Process Organic Acid Metabolic Process Lipid Oxidation Peroxisome Organization Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Peroxisomal Membrane Transport Peroxisomal Membrane Lipid Modification Protein Import Into Peroxisome Matrix, Receptor Recycling Intracellular Protein Transmembrane Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Small Molecule Metabolic Process Lipid Metabolic Process Protein Unfolding Lipid Catabolic Process Protein Transmembrane Transport Catabolic Process Fatty Acid Beta-oxidation Receptor Recycling Protein Targeting To Peroxisome Cytosol Establishment Of Protein Localization To Organelle Receptor Metabolic Process Sulfur Compound Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Import Into Peroxisome Matrix, Substrate Release Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Oxidoreductase Activity Protein Localization To Organelle Purine-containing Compound Metabolic Process Small Molecule Biosynthetic Process Peroxisomal Importomer Complex Malonyl-CoA Catabolic Process Protein Transmembrane Transporter Activity Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Telomere Assembly Organophosphate Metabolic Process	Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Lewy Body Core Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Temperature-gated Cation Channel Activity Response To Arachidonate Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Arachidonate Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Response To Ultrasound Response To Alkaline PH Mechanosensitive Potassium Channel Activity Subcortical Maternal Complex Cytoplasmic Lattice Protein Storage Structural Constituent Of Cytoplasmic Lattice UDP-N-acetylglucosamine Transferase Complex N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Circadian Rhythm Lipid Modification Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Myelin Sheath Adaxonal Region Regulation Of Developmental Process Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Multicellular Organismal Development Regulation Of Synaptic Vesicle Clustering Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Cycle G1/S Phase Transition Postsynaptic Density Assembly