CNOT10 and OBI1

Number of citations of the paper that reports this interaction (PubMedID 34887419)
102

Data Source:
BioGRID (pull down)

		CNOT10	OBI1
Description		CCR4-NOT transcription complex subunit 10	ORC ubiquitin ligase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex	Chromatin Chromosome
	Molecular Function	Protein Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing	Regulation Of DNA Replication Protein Monoubiquitination Protein Autoubiquitination
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Cyclin A/B1/B2 associated events during G2/M transition
Drugs
Diseases
GWAS		Diabetic retinopathy in type 2 diabetes ( 33607655) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Sensorimotor dexterity ( 31596458)
Interacting Genes		4 interacting genes: CHMP1B LTB4R2 OBI1 RNF10	13 interacting genes: CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6 CNOT7 CNOT9 PNKP SRPK2 TCEANC UBE2D1 UBE2D2
Entrez ID		25904	79596
HPRD ID		16731	12619
Ensembl ID		ENSG00000182973	ENSG00000152193
Uniprot IDs		Q9H9A5	Q5W0B1
PDB IDs		8BFI 8FY3
Enriched GO Terms of Interacting Partners?		Protein Autoubiquitination Protein Monoubiquitination Ubiquitin Protein Ligase Activity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Leukotriene Signaling Pathway Keratinocyte Migration Negative Regulation Of Adenylate Cyclase Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity ESCRT III Complex MIT Domain Binding Amphisome Membrane Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Viral Budding From Plasma Membrane Lysosomal Membrane Organization Multivesicular Body-lysosome Fusion Modification-dependent Protein Catabolic Process Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Repair Mitotic Cytokinetic Process Multivesicular Body Membrane Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Midbody Abscission Membrane Coat Protein Ubiquitination Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Epithelial Cell Migration Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation G Protein-coupled Peptide Receptor Activity Regulation Of Mitotic Spindle Organization Late Endosome To Vacuole Transport	CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Regulatory NcRNA-mediated Gene Silencing RNA Catabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process Poly(A)-specific Ribonuclease Activity Regulation Of Translation Macromolecule Catabolic Process Post-transcriptional Regulation Of Gene Expression RNA Metabolic Process Nucleic Acid Metabolic Process P-body Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nucleobase-containing Compound Metabolic Process Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Gene Expression Nucleus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Organelle Assembly MRNA Destabilization RNA Exonuclease Activity RNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
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