KIAA1217 and ABI1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIAA1217	ABI1
Description		KIAA1217	abl interactor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Filopodium Growth Cone SCAR Complex Cell Leading Edge Filopodium Tip Cell Projection Neuron Projection Synapse Extracellular Exosome Actin-based Cell Projection
	Molecular Function	Protein Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity Cadherin Binding
	Biological Process	Embryonic Skeletal System Development	Somitogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Megakaryocyte Development Dendrite Morphogenesis Cell Projection Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Breast cancer and/or colorectal cancer ( 29698419) Cognitive function in longevity ( 33607172) Cognitive performance ( 20125193) Coronary artery disease ( 29212778) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Homeostasis model assessment of insulin resistance ( 33381925) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Moderate-to-late spontaneous preterm birth ( 31194736) Obesity (early onset extreme) ( 23563609) Schizophrenia ( 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		23 interacting genes: ABI1 ABI2 ALKBH7 EXOC8 EXOSC5 FHL2 FXR2 GCC1 GOLGA2 HSBP1 INCA1 KRT15 KRT27 KRT31 NCK2 PTK6 RINT1 SIAH1 SORBS3 TEX11 TRAF1 TRAF2 VPS52	67 interacting genes: ABL1 AKT1 APBB1 C22orf15 CACNA1A CCDC57 CCHCR1 CYFIP2 DST DTNB EIF3H ENAH ENKD1 EPS8 EPS8L1 EVL FAM124B FBXL19 FHL2 FXR1 GAS7 HHEX HNRNPK HOMER1 HOMER3 HSPA8 KIAA0408 KIAA1217 KTN1 LMO1 MAB21L2 MINK1 MRFAP1 MRFAP1L1 NCK1 NCK2 NCKAP1 NEB NFASC NIN OGT PAK2 PCM1 PRKAA2 PRPF40A RBM15 RCOR3 SHANK3 SMARCD1 SORBS1 SORBS2 SOS1 SOS2 SPTA1 SPTAN1 SRP68 SRRM1 SYNE2 TCERG1 TLN1 TRIP10 TSC1 TTC23 VARS2 VASP WASF1 WASF2
Entrez ID		56243	10006
HPRD ID		11132	04336
Ensembl ID		ENSG00000120549	ENSG00000136754
Uniprot IDs		B7ZM29 Q5T5P2	A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0
PDB IDs			7LXE
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity Supramolecular Fiber Organization Cytosol Identical Protein Binding Positive Regulation Of Apoptotic Signaling Pathway Actin-based Cell Projection Structural Constituent Of Skin Epidermis Thioesterase Binding SCAR Complex Intermediate Filament Organization Regulation Of Apoptotic Signaling Pathway Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Protein Kinase Activity Filopodium Tip Structural Constituent Of Cytoskeleton Regulation Of Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Cytoskeletal Anchor Activity Golgi Vesicle Transport Tumor Necrosis Factor Receptor Binding Cytoplasm Regulation Of Protein Modification Process Intermediate Filament Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly Vesicle Membrane Meiotic Gene Conversion Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Protein Phosphorylation Lamellipodium Organization Structural Molecule Activity Negative Regulation Of Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Cytoskeleton Organization Regulation Of Apoptotic Process Syntaxin Binding Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Atrial Cardiac Muscle Cell Development Cellular Developmental Process Cytoskeleton Regulation Of Phosphorylation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Actin Polymerization Or Depolymerization Zonula Adherens Assembly	Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Cytoskeleton Organization Actin Binding Cell Projection Regulation Of Actin Filament Length Regulation Of Cellular Component Size Cell Projection Organization Cytoskeleton Organization Regulation Of Actin Filament Polymerization Lamellipodium Postsynaptic Density Regulation Of Actin Polymerization Or Depolymerization Actin Filament Organization Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Organelle Organization Cytoplasm Supramolecular Fiber Organization SCAR Complex Protein Binding Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Translational Initiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Cadherin Binding Synapse Positive Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Actin Filament Polymerization Organelle Organization Cytoskeleton Cytosol Rac Protein Signal Transduction Negative Regulation Of Supramolecular Fiber Organization Actin Polymerization Or Depolymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Anchoring Junction Positive Regulation Of Cellular Component Biogenesis SH3 Domain Binding Positive Regulation Of Cellular Component Organization Cell Cortex Profilin Binding
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