KIAA1217 and EXOSC5

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KIAA1217	EXOSC5
Gene Name		KIAA1217	exosome component 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Molecular_function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Embryonic Skeletal System Development	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		14 interactors: ABI2 EXOSC5 FHL2 FXR2 GCC1 GOLGA2 HSBP1 KRT15 NCK2 SIAH1 SORBS3 TEX11 TRAF1 VPS52	32 interactors: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 GOLGA2 IKZF3 KIAA1217 KRT13 LIPG LSM5 MPP6 NUP210 PA2G4 PKM POLR2L REL SFPQ SKIV2L2 TNFAIP1 TRIM54 ZNF558
Entrez ID		56243	56915
HPRD ID		11132	16222
Ensembl ID		ENSG00000120549	ENSG00000077348
Uniprot IDs		Q5T5P2	M0R050 Q9NQT4
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?			Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Metabolic Process Maturation Of 5.8S RRNA Nuclear MRNA Surveillance Aromatic Compound Catabolic Process RNA Surveillance Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Nucleic Acid Phosphodiester Bond Hydrolysis TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing Cellular Metabolic Process RNA Localization DNA Deamination Immune System Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Immune Response Leukocyte Activation Isotype Switching
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