KIAA1217 and PTK6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIAA1217	PTK6
Description		KIAA1217	protein tyrosine kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Cell Projection
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding
	Biological Process	Embryonic Skeletal System Development	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation ERBB2 Signaling Pathway Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways			SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization Cytoprotection by HMOX1
Drugs			Vandetanib Tivozanib Fostamatinib Zanubrutinib
Diseases
GWAS		Breast cancer and/or colorectal cancer ( 29698419) Cognitive function in longevity ( 33607172) Cognitive performance ( 20125193) Coronary artery disease ( 29212778) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Homeostasis model assessment of insulin resistance ( 33381925) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Moderate-to-late spontaneous preterm birth ( 31194736) Obesity (early onset extreme) ( 23563609) Schizophrenia ( 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)
Interacting Genes		23 interacting genes: ABI1 ABI2 ALKBH7 EXOC8 EXOSC5 FHL2 FXR2 GCC1 GOLGA2 HSBP1 INCA1 KRT15 KRT27 KRT31 NCK2 PTK6 RINT1 SIAH1 SORBS3 TEX11 TRAF1 TRAF2 VPS52	35 interacting genes: ACTN3 ANKRD55 APP AR CBLB CCDC33 DDX17 DOK1 DTX3 EFHC2 EGFR ERBB2 ERBB3 ERBB4 EXOC5 FCHO1 FGFR1 GAB1 HIF1A KHDRBS1 KHDRBS2 KIAA1217 KIT LINC01139 MEIS2 MET MKRN3 MYOZ3 PITX1 PRDM6 REL SLA STAP2 WASL ZNF341
Entrez ID		56243	5753
HPRD ID		11132	03594
Ensembl ID		ENSG00000120549	ENSG00000101213
Uniprot IDs		B7ZM29 Q5T5P2	Q13882
PDB IDs			1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4 8S1C
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity Supramolecular Fiber Organization Cytosol Identical Protein Binding Positive Regulation Of Apoptotic Signaling Pathway Actin-based Cell Projection Structural Constituent Of Skin Epidermis Thioesterase Binding SCAR Complex Intermediate Filament Organization Regulation Of Apoptotic Signaling Pathway Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Protein Kinase Activity Filopodium Tip Structural Constituent Of Cytoskeleton Regulation Of Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Cytoskeletal Anchor Activity Golgi Vesicle Transport Tumor Necrosis Factor Receptor Binding Cytoplasm Regulation Of Protein Modification Process Intermediate Filament Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly Vesicle Membrane Meiotic Gene Conversion Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Protein Phosphorylation Lamellipodium Organization Structural Molecule Activity Negative Regulation Of Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Cytoskeleton Organization Regulation Of Apoptotic Process Syntaxin Binding Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Atrial Cardiac Muscle Cell Development Cellular Developmental Process Cytoskeleton Regulation Of Phosphorylation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Actin Polymerization Or Depolymerization Zonula Adherens Assembly	Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway SH2 Domain Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway ERBB3:ERBB2 Complex Visual Learning Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Visual Behavior Positive Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Response To Growth Factor ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Regulation Of DNA-templated Transcription Associative Learning Regulation Of RNA Biosynthetic Process Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation
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