APLP2 and DEDD

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		APLP2	DEDD
Gene Name		amyloid beta (A4) precursor-like protein 2	death effector domain containing
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleolus Cytoplasm
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Suckling Behavior Cellular Copper Ion Homeostasis Regulation Of Epidermal Growth Factor-activated Receptor Activity G-protein Coupled Receptor Signaling Pathway Mating Behavior Locomotory Behavior Cholesterol Metabolic Process Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Forebrain Development Midbrain Development Regulation Of Protein Binding Neuromuscular Process Controlling Balance	Transcription, DNA-templated Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ADIPOR1 AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 VKORC1 ZNF512B	16 interactors: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3
Entrez ID		334	9191
HPRD ID		00103	06022
Ensembl ID		ENSG00000084234	ENSG00000158796
Uniprot IDs		B4E3I5 Q06481	B1AQP5 B4DKM1 O75618
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Response To Radiation Negative Regulation Of Cell Death Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Positive Regulation Of Gene Expression Response To Growth Factor Cellular Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Apoptotic Process Response To Cytokine Signal Transduction Programmed Cell Death Response To External Stimulus Cell Death Response To Stimulus Death Positive Regulation Of Metabolic Process Response To Stress Intracellular Signal Transduction Response To Abiotic Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Cell Communication Regulation Of Transcription, DNA-templated Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Regulation Of Growth Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of RNA Metabolic Process Regulation Of Cell Adhesion Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Response To Hormone	Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Proteolysis Regulation Of Proteolysis Hepatocyte Apoptotic Process Regulation Of Necroptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Necrotic Cell Death Viral Process TRAIL-activated Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Positive Regulation Of Apoptotic Signaling Pathway Neuron Apoptotic Process TRNA Transcription Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Neuron Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Execution Phase Of Apoptosis Negative Regulation Of Programmed Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Death Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Positive Regulation Of Hydrolase Activity
Tagcloud ?		allowed app backgroundamyloid conclusionsthe cooperative fertility interacting interactome male members modules motility network networks ontologyand oocyte outside playing reproduction reproductive resultswe screen shed specified sperm spermatozoa superfamily testis topological	actinobacteria cleaving detectable distant divergent duplex equivalent exoribonuclease founding homology hundreds hypothetical kingdom maintain mediating orthologs overhangs pathogen phylogenetically pool prevalent proteobacteria reveals ribonucleases rnase rnases rv2179c similarity strand
Tagcloud (Difference) ?		allowed app backgroundamyloid conclusionsthe cooperative fertility interacting interactome male members modules motility network networks ontologyand oocyte outside playing reproduction reproductive resultswe screen shed specified sperm spermatozoa superfamily testis topological	actinobacteria cleaving detectable distant divergent duplex equivalent exoribonuclease founding homology hundreds hypothetical kingdom maintain mediating orthologs overhangs pathogen phylogenetically pool prevalent proteobacteria reveals ribonucleases rnase rnases rv2179c similarity strand
Tagcloud (Intersection) ?