APLP2 and APBB2

Number of citations of the paper that reports this interaction (PMID 8855266)
17

Data Source:
HPRD (in vivo)

		APLP2	APBB2
Gene Name		amyloid beta (A4) precursor-like protein 2	amyloid beta (A4) precursor protein-binding, family B, member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Membrane Lamellipodium Growth Cone Synapse
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding	Beta-amyloid Binding Protein Binding Transcription Factor Binding
	Biological Process	Suckling Behavior Cellular Copper Ion Homeostasis Regulation Of Epidermal Growth Factor-activated Receptor Activity G-protein Coupled Receptor Signaling Pathway Mating Behavior Locomotory Behavior Cholesterol Metabolic Process Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Forebrain Development Midbrain Development Regulation Of Protein Binding Neuromuscular Process Controlling Balance	Neuron Migration Regulation Of Transcription, DNA-templated Cell Cycle Arrest Axon Guidance Extracellular Matrix Organization Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS			Dental caries ( 23259602)
Protein-Protein Interactions		23 interactors: ADIPOR1 AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 VKORC1 ZNF512B	5 interactors: APLP2 APP EGFR SMAD4 SMURF1
Entrez ID		334	323
HPRD ID		00103	04088
Ensembl ID		ENSG00000084234	ENSG00000163697
Uniprot IDs		B4E3I5 Q06481	B4DJ88 B4E2F2 G5E9Y1 Q92870
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Response To Radiation Negative Regulation Of Cell Death Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Positive Regulation Of Gene Expression Response To Growth Factor Cellular Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Apoptotic Process Response To Cytokine Signal Transduction Programmed Cell Death Response To External Stimulus Cell Death Response To Stimulus Death Positive Regulation Of Metabolic Process Response To Stress Intracellular Signal Transduction Response To Abiotic Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Cell Communication Regulation Of Transcription, DNA-templated Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Regulation Of Growth Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of RNA Metabolic Process Regulation Of Cell Adhesion Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Response To Hormone	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cellular Copper Ion Homeostasis Regulation Of Peptidyl-tyrosine Phosphorylation Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Protein Metabolic Process Regulation Of Binding Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Signaling Axon Guidance Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorylation Mating Forebrain Development Regulation Of Protein Tyrosine Kinase Activity Regulation Of Phosphorus Metabolic Process Metal Ion Homeostasis Regulation Of Cellular Ketone Metabolic Process BMP Signaling Pathway Neuromuscular Process Controlling Balance Axonogenesis Regulation Of BMP Signaling Pathway Ion Homeostasis Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Protein Import Into Nucleus Behavior Response To Growth Factor Chemotaxis Feeding Behavior Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Alkanesulfonate Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Activation Regulation Of Cellular Protein Metabolic Process Cholesterol Metabolic Process Regulation Of Receptor Activity Negative Regulation Of Protein Catabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity
Tagcloud ?		allowed app backgroundamyloid conclusionsthe cooperative fertility interacting interactome male members modules motility network networks ontologyand oocyte outside playing reproduction reproductive resultswe screen shed specified sperm spermatozoa superfamily testis topological	add amyloid arise built covarying drives driving epistatic explained glycogen gsk gsk3beta initiative modify neuroimaging pathology pathophysiology plaque positron precedes reached rs2585590 rs3098914 rs334543 rs457581 served tau theoretical variance
Tagcloud (Difference) ?		allowed app backgroundamyloid conclusionsthe cooperative fertility interacting interactome male members modules motility network networks ontologyand oocyte outside playing reproduction reproductive resultswe screen shed specified sperm spermatozoa superfamily testis topological	add amyloid arise built covarying drives driving epistatic explained glycogen gsk gsk3beta initiative modify neuroimaging pathology pathophysiology plaque positron precedes reached rs2585590 rs3098914 rs334543 rs457581 served tau theoretical variance
Tagcloud (Intersection) ?