APLP2 and APBB2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		APLP2	APBB2
Description		amyloid beta precursor like protein 2	amyloid beta precursor protein binding family B member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Platelet Alpha Granule Platelet Alpha Granule Membrane Extracellular Exosome	Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Membrane Lamellipodium Growth Cone Synapse
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding	Amyloid-beta Binding Protein Binding Molecular Adaptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Axonogenesis Central Nervous System Development	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Smooth Muscle Contraction Axon Guidance Extracellular Matrix Organization Intracellular Signal Transduction Maintenance Of Lens Transparency Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Negative Regulation Of Cell Cycle Phase Transition
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576)	Dental caries ( 23259602) Glaucoma (primary open-angle) ( 31688885) Height ( 28552196) Iris color (L* coordinate) ( 29109912) Opioid sensitivity ( 24143882) Response to citalopram or escitalopram in depression ( 27622933) Severe insulin-resistant type 2 diabetes ( 34737425)
Interacting Genes		25 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 GNAO1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 UBC VKORC1 ZNF512B	9 interacting genes: APLP2 APP MAPK8 NFKB1 SMAD4 SMURF1 TP53 TRADD WWOX
Entrez ID		334	323
HPRD ID		00103	04088
Ensembl ID		ENSG00000084234	ENSG00000163697
Uniprot IDs		A0A140VJE9 B4E3I5 Q06481	B4DJ88 B4E2F2 G5E9Y1 Q5I0G1 Q92870
PDB IDs		5JBT 5TPT 8RQ6
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Leading Edge Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Peptidyl-threonine Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Macromolecule Metabolic Process Low-density Lipoprotein Particle Receptor Binding Protein Localization To Site Of Double-strand Break Amyloid-beta Binding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Establishment Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Response To Lipid Response To Steroid Hormone Regulation Of Cell Adhesion Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signaling Cassette Integrated Stress Response Signaling Transcription Factor AP-1 Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of MiRNA Metabolic Process Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Transcription Coactivator Binding Histone Deacetylase Regulator Activity Signal Transduction Identical Protein Binding Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Wnt Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process I-SMAD Binding Enzyme Binding Transition Metal Ion Binding Platelet Alpha Granule Apoptotic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Central Nervous System Development Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Cell Death Regulation Of Hair Follicle Development Protein Serine/threonine Kinase Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Inflammatory Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Molecular Function Activator Activity R-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Hair Cycle Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Non-canonical NF-kappaB Signal Transduction Response To Mechanical Stimulus Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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