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APLP2 and PIK3CA
Number of citations of the paper that reports this interaction (PubMedID
10490823
)
0
Data Source:
HPRD
(in vivo)
APLP2
PIK3CA
Description
amyloid beta precursor like protein 2
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Image
GO Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum Lumen
Plasma Membrane
Membrane
Platelet Alpha Granule
Platelet Alpha Granule Membrane
Extracellular Exosome
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Phosphatidylinositol 3-kinase Complex, Class IB
Intercalated Disc
Lamellipodium
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Heparin Binding
Peptidase Inhibitor Activity
Identical Protein Binding
Metal Ion Binding
Transition Metal Ion Binding
Nucleotide Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
Protein Kinase Activator Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Insulin Receptor Substrate Binding
1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Protein Serine Kinase Activity
Biological Process
G Protein-coupled Receptor Signaling Pathway
Axonogenesis
Central Nervous System Development
Angiogenesis
Liver Development
Vasculature Development
Glucose Metabolic Process
Lipid Metabolic Process
Phagocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Gene Expression
Positive Regulation Of Lamellipodium Assembly
Negative Regulation Of Gene Expression
Response To Activity
Response To Muscle Inactivity
Negative Regulation Of Macroautophagy
Cell Migration
Actin Cytoskeleton Organization
Platelet Activation
Negative Regulation Of Actin Filament Depolymerization
Positive Regulation Of TOR Signaling
Cellular Response To Insulin Stimulus
Response To Muscle Stretch
Phosphatidylinositol-3-phosphate Biosynthetic Process
Vascular Endothelial Growth Factor Signaling Pathway
Regulation Of Multicellular Organism Growth
Response To L-leucine
Anoikis
Regulation Of Cellular Respiration
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Neuron Apoptotic Process
Endothelial Cell Migration
Phosphatidylinositol Phosphate Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
T Cell Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Relaxation Of Cardiac Muscle
Cardiac Muscle Contraction
Adipose Tissue Development
Cellular Response To Glucose Stimulus
Cellular Response To Hydrostatic Pressure
Response To Dexamethasone
Cardiac Muscle Cell Contraction
Energy Homeostasis
Regulation Of Actin Filament Organization
Autosome Genomic Imprinting
Response To Butyrate
Positive Regulation Of Protein Localization To Membrane
Negative Regulation Of Fibroblast Apoptotic Process
Negative Regulation Of Anoikis
Pathways
Platelet degranulation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
Extra-nuclear estrogen signaling
RAC1 GTPase cycle
RAC2 GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Signaling by LTK in cancer
Signaling by LTK
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Co-stimulation by ICOS
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
ATP
Caffeine
XL765
Wortmannin
Pilaralisib
Alpelisib
Copanlisib
Diseases
Ovarian cancer
GWAS
Blood protein levels (
30072576
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
25 interacting genes:
AKT1
APBB1
APBB2
APBB3
BRCA1
CDK1
DAB1
DAB2
DEDD
ETS1
GNAO1
HGS
HLA-A
JUN
JUNB
KAT5
MAPK8
PIK3CA
PRKCA
PRNP
RPL26
SLC13A1
UBC
VKORC1
ZNF512B
69 interacting genes:
ADAP1
AKT1
AMBP
APLP2
APPL1
ARAF
ATP5IF1
ATR
BEX1
BEX2
CCND2
CSF1R
CYTH2
CYTH3
DDX5
DNAJB6
EGFR
FANCC
FASLG
FBP2
FTL
GABRB1
GALNT12
GLIS2
GNAQ
GRIN2B
HRAS
IL13RA2
IL24
IL3
IRS2
IRS4
ITIH1
KRAS
LCK
MAP2K1
MRAS
MYC
NEDD9
NRAS
PDGFRA
PDGFRB
PDK1
PIK3R1
PIK3R3
PRKCD
PSMC3IP
PTPN11
RASD2
RASGRP3
RELA
RPS20
RPS6KB1
SFRP4
SGK1
SH3KBP1
SMAD2
SMAD3
SNX9
SQSTM1
STAT1
STK11
THRSP
TICAM1
TMOD1
TNFSF13
UFD1
UMPS
VARS2
Entrez ID
334
5290
HPRD ID
00103
01382
Ensembl ID
ENSG00000084234
ENSG00000121879
Uniprot IDs
A0A140VJE9
B4E3I5
Q06481
P42336
PDB IDs
5JBT
5TPT
8RQ6
2ENQ
2RD0
3HHM
3HIZ
3ZIM
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4TUU
4TV3
4WAF
4YKN
4ZOP
5DXH
5DXT
5FI4
5ITD
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBR
5UK8
5UKJ
5UL1
5XGH
5XGI
5XGJ
6GVF
6GVG
6GVH
6GVI
6NCT
6OAC
6PYS
6VO7
7JIU
7K6M
7K6N
7K6O
7K71
7L1B
7L1C
7L1D
7MLK
7MYN
7MYO
7PG5
7PG6
7R9V
7R9Y
7RRG
7TZ7
8AM0
8BFU
8DCP
8DCX
8DD4
8DD8
8EXL
8EXO
8EXU
8EXV
8GUA
8GUB
8GUD
8ILR
8ILS
8ILV
8OW2
8SBC
8SBJ
8TDU
8TGD
8TS7
8TS8
8TS9
8TSA
8TSB
8TSC
8TSD
8TU6
8TWY
8V8H
8V8I
8V8J
8V8U
8V8V
8VCL
8W9A
8W9B
9ASF
9ASG
9B4S
9B4T
9C15
9E8M
Enriched GO Terms of Interacting Partners
?
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Biosynthetic Process
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of Gene Expression
Regulation Of Protein Localization
Regulation Of Multicellular Organismal Process
Signal Transduction
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Leading Edge Cell Differentiation
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Protein Localization
Apoptotic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Peptidyl-threonine Phosphorylation
Programmed Cell Death
Cell Death
Positive Regulation Of Establishment Of Protein Localization
Positive Regulation Of Macromolecule Metabolic Process
Low-density Lipoprotein Particle Receptor Binding
Protein Localization To Site Of Double-strand Break
Amyloid-beta Binding
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Establishment Of Protein Localization
Negative Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Metabolic Process
Response To Lipid
Response To Steroid Hormone
Regulation Of Cell Adhesion
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Intracellular Signaling Cassette
Integrated Stress Response Signaling
Transcription Factor AP-1 Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Transcription By RNA Polymerase II
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Protein Kinase Activity
Intracellular Signaling Cassette
Regulation Of Apoptotic Process
Insulin Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Cytosol
Kinase Activity
Positive Regulation Of D-glucose Import
Cytoplasm
Cell Population Proliferation
Regulation Of Protein Localization To Cell Periphery
Response To UV
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of D-glucose Transmembrane Transport
Cell Migration
Nucleotide Binding
Negative Regulation Of Programmed Cell Death
Response To Radiation
Regulation Of Protein Localization
Regulation Of Protein Localization To Membrane
Phospholipase C Activator Activity
MAPK Cascade
Response To Hormone
Protein Kinase Binding
Regulation Of Protein Modification Process
Cell Motility
Response To Growth Factor
Response To Light Stimulus
Negative Regulation Of Apoptotic Process
Apoptotic Signaling Pathway
Regulation Of D-glucose Import
Positive Regulation Of Gene Expression
Regulation Of Actin Cytoskeleton Organization
Protein Phosphorylation
Positive Regulation Of Metabolic Process
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