APLP2 and RPL26

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		APLP2	RPL26
Name		amyloid beta precursor like protein 2	ribosomal protein L26
Structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Platelet Alpha Granule Platelet Alpha Granule Membrane Extracellular Exosome	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding MRNA 5'-UTR Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Axonogenesis Central Nervous System Development	Cytoplasmic Translation RRNA Processing Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To UV Ribosomal Large Subunit Biogenesis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Translation Cellular Response To Gamma Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Translation Involved In Cellular Response To UV
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
GWAS		Blood protein levels ( 30072576 )	No GWAS studies recorded
Interacting Genes		25 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 GNAO1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 UBC VKORC1 ZNF512B	9 interacting genes: APLP2 EIF4ENIF1 FBXO7 HNRNPR MDM2 NAA10 NAA15 NAA16 SAYSD1
Entrez ID		334	6154
HPRD ID		00103	04746
Ensembl ID		ENSG00000084234	ENSG00000161970
Uniprot IDs		A0A140VJE9 B4E3I5 Q06481	P61254
PDB IDs		5JBT 5TPT 8RQ6	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SXO 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8ONY 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9G8M 9GMO
GO Terms Enriched among Interactors		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Leading Edge Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Peptidyl-threonine Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Macromolecule Metabolic Process Low-density Lipoprotein Particle Receptor Binding Protein Localization To Site Of Double-strand Break Amyloid-beta Binding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Establishment Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Response To Lipid Response To Steroid Hormone Regulation Of Cell Adhesion Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signaling Cassette Integrated Stress Response Signaling Transcription Factor AP-1 Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II	NatA Complex N-terminal Protein Amino Acid Acetylation Acetyltransferase Activity Protein Acetylation Ribosome Binding Acetyltransferase Activator Activity Regulation Of Protein Stability Protein Metabolic Process Macromolecule Metabolic Process Response To Formaldehyde Cellular Response To Vitamin B1 Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein Maturation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Apoptotic Process Protein Modification Process Negative Regulation Of Programmed Cell Death Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Response To Vitamin B1 Response To Water-immersion Restraint Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Ubiquitin Binding Cellular Response To Actinomycin D Protein N-terminal-serine Acetyltransferase Activity Lewy Body Core UFM1-modified Protein Reader Activity NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Nucleus Positive Regulation Of Catabolic Process Cellular Response To UV-C Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion Regulation Of G1/S Transition Of Mitotic Cell Cycle Receptor Serine/threonine Kinase Binding Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Localization To Nucleus Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Proteolysis Involved In Protein Catabolic Process Atrial Septum Development