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EIF2AK2 and DHX9
Number of citations of the paper that reports this interaction (PMID
19229320
)
11
Data Source:
BioGRID
(enzymatic study)
EIF2AK2
DHX9
Gene Name
eukaryotic translation initiation factor 2-alpha kinase 2
DEAH (Asp-Glu-Ala-His) box helicase 9
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Membrane
Ribonucleoprotein Complex
Cytoplasmic Ribonucleoprotein Granule
CRD-mediated MRNA Stability Complex
Molecular Function
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Type 2A Regulator Activity
Poly(A) RNA Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
RNA Helicase Activity
ATP-dependent DNA Helicase Activity
ATP-dependent RNA Helicase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Biological Process
Activation Of MAPKK Activity
Positive Regulation Of Cytokine Production
Transcription, DNA-templated
Translation
Protein Phosphorylation
Negative Regulation Of Cell Proliferation
Response To Virus
Negative Regulation Of Translation
Peptidyl-tyrosine Phosphorylation
Modulation By Virus Of Host Morphology Or Physiology
Modulation By Virus Of Host Process
Viral Life Cycle
Evasion Or Tolerance By Virus Of Host Immune Response
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Response To Interferon-alpha
Negative Regulation Of Apoptotic Process
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
RNA Processing
Circadian Rhythm
RNA Splicing
Gene Expression
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Cellular Response To Heat
Innate Immune Response
CRD-mediated MRNA Stabilization
Pathways
ISG15 antiviral mechanism
Interferon Signaling
Inhibition of PKR
Cytokine Signaling in Immune system
Host Interactions with Influenza Factors
Influenza Infection
NS1 Mediated Effects on Host Pathways
Antiviral mechanism by IFN-stimulated genes
mRNA Splicing
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
Processing of Capped Intron-Containing Pre-mRNA
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
mRNA Splicing - Major Pathway
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions
48 interactors:
CASP3
CASP7
CASP8
CDC42
CHUK
DHX30
DHX58
DHX9
DICER1
DNAJC3
EDC4
EIF2S1
EIF6
ELF2
FTSJ3
HIST2H2AC
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
MAP3K5
MAP3K7
METAP2
MOV10
NFKBIA
NPM1
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PRKRIR
PTGES3
RAC1
STAT1
STAT3
STRBP
TAB2
TARBP2
TIRAP
TOLLIP
TP53
TYK2
ZNF346
40 interactors:
ACTA1
AKAP8L
APBB1
BRCA1
DDX20
DDX5
EIF2AK2
EWSR1
GEMIN2
GEMIN4
GTF2B
H2AFX
HDLBP
HNRNPC
HNRNPK
IL7R
ILF3
JUN
KHDRBS1
MBD2
MGEA5
NXF1
PCNA
POLR2A
PRMT1
PRPF40A
PRPF8
RBM4
RELA
SMN1
SMN2
SNRPB
SNRPB2
SRPK1
SSRP1
STAU1
TBP
TOP2A
UBE2I
YWHAQ
Entrez ID
5610
1660
HPRD ID
01468
04386
Ensembl ID
ENSG00000055332
ENSG00000135829
Uniprot IDs
B7ZKK7
P19525
Q8IW76
B3KU66
Q08211
PDB IDs
1QU6
2A19
2A1A
3UIU
3LLM
3VYX
3VYY
Enriched GO Terms of Interacting Partners
?
Immune Response
Defense Response
Immune System Process
Innate Immune Response
Response To Stress
Response To Organic Substance
Cellular Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Metabolic Process
Response To Stimulus
Regulation Of Cell Death
Response To External Stimulus
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Stimulus
Regulation Of Apoptotic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Posttranscriptional Regulation Of Gene Expression
Cellular Response To Growth Factor Stimulus
Response To Biotic Stimulus
Response To Abiotic Stimulus
Signaling
Response To Growth Factor
Response To Virus
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Kinase Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Metabolic Process
Response To DsRNA
Positive Regulation Of Intracellular Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
MRNA Processing
RNA Splicing
MRNA Metabolic Process
RNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Spliceosomal SnRNP Assembly
Nitrogen Compound Metabolic Process
Regulation Of Viral Process
Regulation Of Viral Genome Replication
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Viral Process
Positive Regulation Of DNA Metabolic Process
Regulation Of Gene Expression
Ribonucleoprotein Complex Assembly
Viral Process
Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Cellular Macromolecular Complex Assembly
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Ribonucleoprotein Complex Biogenesis
Negative Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Chromosome Organization
Positive Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Viral Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Viral Genome Replication
Tagcloud
?
c1qdc1
cds1
crebbp
ctnnd1
cul1
customized
dner
eef2
fzd2
fzd9
g93a
gastrocnemius
id2
inppl1
keep
loxl2
neuromuscular
pi3
pik3c2a
pik4ca
piki3r1
precede
presymptomatic
prkx
rac3
ripk4
snf1lk
sod1
tbl1x
Tagcloud (Difference)
?
c1qdc1
cds1
crebbp
ctnnd1
cul1
customized
dner
eef2
fzd2
fzd9
g93a
gastrocnemius
id2
inppl1
keep
loxl2
neuromuscular
pi3
pik3c2a
pik4ca
piki3r1
precede
presymptomatic
prkx
rac3
ripk4
snf1lk
sod1
tbl1x
Tagcloud (Intersection)
?