NKRF and DHX15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NKRF	DHX15
Description		NFKB repressing factor	DEAH-box helicase 15
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus Nuclear Speck U2-type Post-mRNA Release Spliceosomal Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific ATPase Activator Activity Nucleic Acid Binding DNA Binding RNA Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	MRNA Splicing, Via Spliceosome Immune System Process MRNA Processing RNA Splicing Response To Toxic Substance Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Alkaloid Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Myopia (pathological) ( 23049088) Pulmonary emphysema ( 24383474) Sense of smell ( 26632684)
Interacting Genes		16 interacting genes: ADARB1 DHX15 DHX58 FILNC1 HMOX2 KIFC1 NFKB1 NFKB2 PRKN PRKRA REL RELA STAU1 TARBP2 USP7 ZNF346	23 interacting genes: AGGF1 APBB1 CAMSAP3 CEBPA DDX42 DYSF FXR1 GPANK1 KRT75 NKAP NKRF PIN1 PRPF40A PTEN PTP4A2 SPOP TRA2A UBC USP7 WBP4 YWHAB YWHAG ZGPAT
Entrez ID		55922	1665
HPRD ID		02341	04553
Ensembl ID		ENSG00000186416	ENSG00000109606
Uniprot IDs		A0AAG2UWQ9 A3F769 O15226	O43143
PDB IDs		6SH6 6SH7	5XDR 6ID1 6SH6 6SH7 8EJM 8RO2
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Gene Expression Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Virus Antiviral Innate Immune Response NF-kappaB P50/p65 Complex Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Viral Genome Replication I-kappaB/NF-kappaB Complex Immune Response Defense Response To Virus NF-kappaB Complex Response To External Biotic Stimulus Immune System Process Response To Stress Response To Oxidative Stress Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nicotine Enzyme Binding RISC-loading Complex SiRNA Processing Positive Regulation Of Viral Process Pre-miRNA Binding Response To Other Organism Negative Regulation Of Metabolic Process Cellular Response To Oxidative Stress RISC Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process SiRNA Binding Regulation Of Viral Genome Replication Negative Regulation Of Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Biosynthetic Process Actinin Binding Pre-miRNA Processing Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Regulatory NcRNA Processing Cellular Response To Angiotensin Cellular Response To Interleukin-6 Cellular Response To Chemical Stress Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Viral Life Cycle Response To Interleukin-6 Negative Regulation Of Phosphorylation	Nucleic Acid Binding Nuclear Speck Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Nucleoplasm Negative Regulation Of Metabolic Process Nucleus Ubiquitin Ligase Activator Activity Negative Regulation Of Protein Metabolic Process RNA Binding MRNA Cis Splicing, Via Spliceosome Proline-rich Region Binding Protein Stabilization U2-type Prespliceosome Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Stem Cell Proliferation Regulation Of Protein Metabolic Process Dentate Gyrus Development Negative Regulation Of Phosphorylation Granulocyte Differentiation Molecular Function Inhibitor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Stability Cis-trans Isomerase Activity Phosphoprotein Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Phosphate Metabolic Process Monocyte Activation Involved In Immune Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Phosphorylation Protein Sequestering Activity
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