DHX15 and DDX42

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		DHX15	DDX42
Gene Name		DEAH (Asp-Glu-Ala-His) box helicase 15	DEAD (Asp-Glu-Ala-Asp) box helicase 42
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm U12-type Spliceosomal Complex Nucleolus Cytoplasm U2-type Post-mRNA Release Spliceosomal Complex	Nucleus Nucleoplasm Cytoplasm Cajal Body Membrane Nuclear Speck
	Molecular Function	RNA Helicase Activity Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Protein Localization Metabolic Process
Pathways
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088)
Protein-Protein Interactions		12 interactors: APBB1 DDX42 NKAP PIN1 PINX1 PRPF40A RBM17 TRA2A WBP4 YWHAB YWHAG ZGPAT	10 interactors: APP DHX15 FBXO25 PRPF19 RECQL5 SF3A1 SF3B4 SNRPC U2SURP UBC
Entrez ID		1665	11325
HPRD ID		04553	09909
Ensembl ID		ENSG00000109606	ENSG00000198231
Uniprot IDs		O43143	Q86XP3
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing Gene Expression Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway MRNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle RNA Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Cytokinesis Negative Regulation Of Transferase Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Thymidylate Synthase Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Regulation Of Protein Phosphorylation Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation Regulation Of Phosphorylation Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Protein Kinase Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Intracellular Transport Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	RNA Processing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Splicing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Regulation Of Cell Cycle Phase Transition Spliceosomal SnRNP Assembly Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway MRNA Splice Site Selection Cellular Metabolic Process Ribonucleoprotein Complex Biogenesis Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Generation Of Catalytic Spliceosome For First Transesterification Step Regulation Of ERBB Signaling Pathway Regulation Of MRNA Processing Signal Transduction In Response To DNA Damage Regulation Of RNA Splicing Synaptic Growth At Neuromuscular Junction Regulation Of Cell Cycle Process Collateral Sprouting In Absence Of Injury Protein Ubiquitination Notch Signaling Pathway MRNA 5'-splice Site Recognition DNA Repair Protein Modification By Small Protein Conjugation DNA Damage Checkpoint Cellular Macromolecular Complex Assembly Collateral Sprouting Axon Midline Choice Point Recognition MRNA 3'-splice Site Recognition Protein Polyubiquitination Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Gene Expression Axon Choice Point Recognition Negative Regulation Of Neuron Differentiation
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