NKRF and NFKB2

Number of citations of the paper that reports this interaction (PubMedID 10562553)
0

Data Source:
HPRD (in vitro)

		NKRF	NFKB2
Description		NFKB repressing factor	nuclear factor kappa B subunit 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific ATPase Activator Activity Nucleic Acid Binding DNA Binding RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction Extracellular Matrix Organization Response To Lipopolysaccharide Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Intracellular Signaling Cassette
Pathways			RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection Regulation of PD-L1(CD274) transcription
Drugs			Sulfasalazine Donepezil Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS			Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: ADARB1 DHX15 DHX58 FILNC1 HMOX2 KIFC1 NFKB1 NFKB2 PRKN PRKRA REL RELA STAU1 TARBP2 USP7 ZNF346	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		55922	4791
HPRD ID		02341	01239
Ensembl ID		ENSG00000186416	ENSG00000077150
Uniprot IDs		A0AAG2UWQ9 A3F769 O15226	Q00653
PDB IDs		6SH6 6SH7	1A3Q 2D96 3DO7 4OT9 5ZMC 7CLI 7VUP 7VUQ 7W7L 8G8Q 8G8S
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Gene Expression Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Virus Antiviral Innate Immune Response NF-kappaB P50/p65 Complex Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Viral Genome Replication I-kappaB/NF-kappaB Complex Immune Response Defense Response To Virus NF-kappaB Complex Response To External Biotic Stimulus Immune System Process Response To Stress Response To Oxidative Stress Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nicotine Enzyme Binding RISC-loading Complex SiRNA Processing Positive Regulation Of Viral Process Pre-miRNA Binding Response To Other Organism Negative Regulation Of Metabolic Process Cellular Response To Oxidative Stress RISC Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process SiRNA Binding Regulation Of Viral Genome Replication Negative Regulation Of Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Biosynthetic Process Actinin Binding Pre-miRNA Processing Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Regulatory NcRNA Processing Cellular Response To Angiotensin Cellular Response To Interleukin-6 Cellular Response To Chemical Stress Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Viral Life Cycle Response To Interleukin-6 Negative Regulation Of Phosphorylation	Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Regulation Of Gene Expression Immune System Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Negative Regulation Of Biosynthetic Process Cytoplasm Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Nucleoplasm Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Defense Response NF-kappaB Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process
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