DHX15 and CAMSAP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DHX15	CAMSAP3
Description		DEAH-box helicase 15	calmodulin regulated spectrin associated protein family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus Nuclear Speck U2-type Post-mRNA Release Spliceosomal Complex	Cytoplasm Centrosome Cytoskeleton Microtubule Adherens Junction Zonula Adherens Axoneme Microtubule Cytoskeleton Replication Fork Protection Complex Motile Cilium Ciliary Basal Body Microtubule Minus-end Cell Projection Anchoring Junction
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity	DNA Binding Protein Binding Calmodulin Binding Microtubule Binding Spectrin Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	MRNA Splicing, Via Spliceosome Immune System Process MRNA Processing RNA Splicing Response To Toxic Substance Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Alkaloid Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response	DNA Replication Checkpoint Signaling Microtubule Cytoskeleton Organization In Utero Embryonic Development Cilium Movement Embryo Development Ending In Birth Or Egg Hatching Cell Projection Organization Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Organelle Organization Microtubule Anchoring Replication Fork Arrest Establishment Of Epithelial Cell Apical/basal Polarity Zonula Adherens Maintenance Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Epithelial Cell-cell Adhesion Protein Transport Along Microtubule Regulation Of Golgi Organization
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Myopia (pathological) ( 23049088) Pulmonary emphysema ( 24383474) Sense of smell ( 26632684)	Diffusing capacity of carbon monoxide ( 30694715)
Interacting Genes		23 interacting genes: AGGF1 APBB1 CAMSAP3 CEBPA DDX42 DYSF FXR1 GPANK1 KRT75 NKAP NKRF PIN1 PRPF40A PTEN PTP4A2 SPOP TRA2A UBC USP7 WBP4 YWHAB YWHAG ZGPAT	7 interacting genes: DHX15 FSD2 GSK3B HSF2BP KATNA1 KATNB1 TUBB3
Entrez ID		1665	57662
HPRD ID		04553	13871
Ensembl ID		ENSG00000109606	ENSG00000076826
Uniprot IDs		O43143	Q9P1Y5
PDB IDs		5XDR 6ID1 6SH6 6SH7 8EJM 8RO2
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Nuclear Speck Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Nucleoplasm Negative Regulation Of Metabolic Process Nucleus Ubiquitin Ligase Activator Activity Negative Regulation Of Protein Metabolic Process RNA Binding MRNA Cis Splicing, Via Spliceosome Proline-rich Region Binding Protein Stabilization U2-type Prespliceosome Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Stem Cell Proliferation Regulation Of Protein Metabolic Process Dentate Gyrus Development Negative Regulation Of Phosphorylation Granulocyte Differentiation Molecular Function Inhibitor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Stability Cis-trans Isomerase Activity Phosphoprotein Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Phosphate Metabolic Process Monocyte Activation Involved In Immune Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Phosphorylation Protein Sequestering Activity	Katanin Complex Microtubule Severing Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Binding Regulation Of Microtubule-based Process Microtubule Cytoskeleton Regulation Of Microtubule Anchoring At Centrosome Excitatory Postsynaptic Potential Hepatocyte Growth Factor Receptor Activity Cytoplasmic Microtubule Organization Microtubule Nucleotide Binding Axon Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity ATPase Regulator Activity Netrin Receptor Binding Regulation Of Postsynaptic Membrane Potential Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization U2-type Post-mRNA Release Spliceosomal Complex Positive Regulation Of Organelle Organization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Cytoskeleton Organization Regulation Of Glycogen (starch) Synthase Activity Pyrimidine Dimer Repair By Nucleotide-excision Repair Post-embryonic Camera-type Eye Morphogenesis Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Microtubule Depolymerization Mitotic Chromosome Movement Towards Spindle Pole Growth Cone Mitotic Spindle Dorsal Root Ganglion Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Spindle Pole Positive Regulation Of Protein Localization To Cilium Microtubule Severing ATPase Activity Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome Post-embryonic Eye Morphogenesis Positive Regulation Of Supramolecular Fiber Organization Female Meiosis I ATP Binding Centrosome
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