DHX15 and NKAP

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		DHX15	NKAP
Description		DEAH-box helicase 15	NFKB activating protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus Nuclear Speck U2-type Post-mRNA Release Spliceosomal Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity	Chromatin Binding RNA Binding Protein Binding Chromatin DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Immune System Process MRNA Processing RNA Splicing Response To Toxic Substance Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Alkaloid Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Hemopoiesis Granulocyte Differentiation T Cell Differentiation In Thymus Somatic Stem Cell Population Maintenance Negative Regulation Of DNA-templated Transcription Positive Regulation Of Alpha-beta T Cell Differentiation Hematopoietic Stem Cell Proliferation
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Myopia (pathological) ( 23049088) Pulmonary emphysema ( 24383474) Sense of smell ( 26632684)
Interacting Genes		23 interacting genes: AGGF1 APBB1 CAMSAP3 CEBPA DDX42 DYSF FXR1 GPANK1 KRT75 NKAP NKRF PIN1 PRPF40A PTEN PTP4A2 SPOP TRA2A UBC USP7 WBP4 YWHAB YWHAG ZGPAT	17 interacting genes: AP1M1 CEP70 DHX15 FAM124A FRA10AC1 LUC7L2 OGT PCBP2 PRPF3 PRPF40A RBM39 RBMX2 SRPK1 SRPK2 THAP1 TTC14 U2AF1
Entrez ID		1665	79576
HPRD ID		04553	06666
Ensembl ID		ENSG00000109606	ENSG00000101882
Uniprot IDs		O43143	Q8N5F7
PDB IDs		5XDR 6ID1 6SH6 6SH7 8EJM 8RO2	6QDV 7W5B 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Nuclear Speck Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Nucleoplasm Negative Regulation Of Metabolic Process Nucleus Ubiquitin Ligase Activator Activity Negative Regulation Of Protein Metabolic Process RNA Binding MRNA Cis Splicing, Via Spliceosome Proline-rich Region Binding Protein Stabilization U2-type Prespliceosome Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Stem Cell Proliferation Regulation Of Protein Metabolic Process Dentate Gyrus Development Negative Regulation Of Phosphorylation Granulocyte Differentiation Molecular Function Inhibitor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Stability Cis-trans Isomerase Activity Phosphoprotein Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Phosphate Metabolic Process Monocyte Activation Involved In Immune Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Phosphorylation Protein Sequestering Activity	RNA Splicing MRNA Metabolic Process MRNA Processing Nuclear Speck RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions RNA Binding Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Spliceosomal Complex Assembly RS Domain Binding Spliceosomal Complex Nucleoplasm U2-type Prespliceosome U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Macromolecule Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of RNA Splicing Protein-containing Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleus Negative Regulation Of Viral Genome Replication Cellular Component Assembly U2-type Precatalytic Spliceosome Positive Regulation Of Viral Process Protein-containing Complex Organization Cajal Body Negative Regulation Of Viral Process Regulation Of Viral Genome Replication U2-type Post-mRNA Release Spliceosomal Complex Protein O-acetylglucosaminyltransferase Activity Innate Immune Response Regulation Of MRNA Metabolic Process Nuclear Speck Organization
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