DHX15 and APBB1

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		DHX15	APBB1
Gene Name		DEAH (Asp-Glu-Ala-His) box helicase 15	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm U12-type Spliceosomal Complex Nucleolus Cytoplasm U2-type Post-mRNA Release Spliceosomal Complex	Nucleus Cytoplasm Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse
	Molecular Function	RNA Helicase Activity Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Beta-amyloid Binding Chromatin Binding Protein Binding Transcription Factor Binding Histone Binding Proline-rich Region Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Neuron Migration Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Axon Guidance Visual Learning Extracellular Matrix Organization Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088)
Protein-Protein Interactions		12 interactors: APBB1 DDX42 NKAP PIN1 PINX1 PRPF40A RBM17 TRA2A WBP4 YWHAB YWHAG ZGPAT	66 interactors: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		1665	322
HPRD ID		04553	04087
Ensembl ID		ENSG00000109606	ENSG00000166313
Uniprot IDs		O43143	O00213
PDB IDs			2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing Gene Expression Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway MRNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle RNA Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Cytokinesis Negative Regulation Of Transferase Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Thymidylate Synthase Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Regulation Of Protein Phosphorylation Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation Regulation Of Phosphorylation Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Protein Kinase Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Intracellular Transport Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process	RNA Processing MRNA Processing MRNA Metabolic Process RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Actin Polymerization Or Depolymerization RNA Biosynthetic Process MRNA 3'-splice Site Recognition Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription, DNA-templated Fc Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Phagocytosis MRNA 3'-end Processing Cellular Process Regulation Of Metabolic Process Endocytosis Innate Immune Response Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Splicing RNA 3'-end Processing Actin Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Developmental Process Actin Filament-based Process MRNA Stabilization Axon Guidance Positive Regulation Of Actin Nucleation MRNA Polyadenylation
Tagcloud ?			a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Difference) ?			a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Intersection) ?