NKRF and DHX58

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		NKRF	DHX58
Gene Name		NFKB repressing factor	DEXH (Asp-Glu-X-His) box polypeptide 58
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Endoplasmic Reticulum	Cytoplasm
	Molecular Function	DNA Binding Protein Binding Poly(A) RNA Binding	DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Metabolic Process Response To Virus Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: DHX58 HMOX2 NFKB1 NFKB2 PRKRA REL RELA	9 interactors: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2
Entrez ID		55922	79132
HPRD ID		02341	13115
Ensembl ID		ENSG00000186416	ENSG00000108771
Uniprot IDs		A3F768 A3F769 O15226	Q96C10
PDB IDs			2RQA 2W4R 3EQT
Enriched GO Terms of Interacting Partners?		NIK/NF-kappaB Signaling Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Toll-like Receptor 5 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Positive Regulation Of MiRNA Metabolic Process Toll-like Receptor 4 Signaling Pathway Response To Stress Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cytokine Biosynthetic Process Response To Oxidative Stress Toll-like Receptor Signaling Pathway Inflammatory Response Regulation Of MiRNA Metabolic Process Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Membrane Protein Intracellular Domain Proteolysis Defense Response Positive Regulation Of Innate Immune Response Cellular Response To Interleukin-6 Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Interleukin-6 Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Intracellular Signal Transduction Membrane Protein Proteolysis	RNA Interference Pre-miRNA Processing Posttranscriptional Regulation Of Gene Expression Production Of MiRNAs Involved In Gene Silencing By MiRNA Ribonucleoprotein Complex Assembly Regulation Of Defense Response To Virus By Virus RNA Processing Gene Expression Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Regulation Of Translation Ribonucleoprotein Complex Biogenesis Gene Silencing By RNA Regulation Of Viral Genome Replication RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of Translational Initiation Response To DsRNA Regulation Of Epidermal Growth Factor Receptor Signaling Pathway RNA Metabolic Process Evasion Or Tolerance By Virus Of Host Immune Response Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation Of Translation Negative Regulation Of Cellular Metabolic Process Immune System Process Gene Silencing RNA Phosphodiester Bond Hydrolysis MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Synaptic Growth At Neuromuscular Junction Zygote Asymmetric Cell Division Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process SiRNA Loading Onto RISC Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Collateral Sprouting In Absence Of Injury Evasion Or Tolerance Of Host Defenses By Virus Notch Signaling Pathway Post-embryonic Development Cellular Macromolecular Complex Assembly Regulation Of Viral Process Neuron Projection Morphogenesis Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Tagcloud ?		alveolar concomitant contact downregulates elucidated endogenous fully heated hinder il interference ip kappab loads macrophages mononuclear mtb mycobacterium p65 recruitment repressing repressive repressor robust serves synthesis tb thp understood
Tagcloud (Difference) ?		alveolar concomitant contact downregulates elucidated endogenous fully heated hinder il interference ip kappab loads macrophages mononuclear mtb mycobacterium p65 recruitment repressing repressive repressor robust serves synthesis tb thp understood
Tagcloud (Intersection) ?