NKRF and PRKRA

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NKRF	PRKRA
Gene Name		NFKB repressing factor	protein kinase, interferon-inducible double stranded RNA dependent activator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Endoplasmic Reticulum	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding Poly(A) RNA Binding	Protein Binding Enzyme Activator Activity Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Protein Phosphorylation Immune Response Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Production Of SiRNA Involved In RNA Interference Cellular Response To Oxidative Stress Outer Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Catalytic Activity Skeletal System Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS			Multiple sclerosis (OCB status) ( 23472185)
Protein-Protein Interactions		7 interactors: DHX58 HMOX2 NFKB1 NFKB2 PRKRA REL RELA	21 interactors: AGO2 CEBPZ COPS6 DICER1 EIF2AK2 GDF9 KIAA1377 LYAR NKRF POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		55922	8575
HPRD ID		02341	04573
Ensembl ID		ENSG00000186416	ENSG00000180228
Uniprot IDs		A3F768 A3F769 O15226	B4DJC7 O75569
PDB IDs			2DIX
Enriched GO Terms of Interacting Partners?		NIK/NF-kappaB Signaling Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Toll-like Receptor 5 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Positive Regulation Of MiRNA Metabolic Process Toll-like Receptor 4 Signaling Pathway Response To Stress Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cytokine Biosynthetic Process Response To Oxidative Stress Toll-like Receptor Signaling Pathway Inflammatory Response Regulation Of MiRNA Metabolic Process Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Membrane Protein Intracellular Domain Proteolysis Defense Response Positive Regulation Of Innate Immune Response Cellular Response To Interleukin-6 Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Interleukin-6 Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Intracellular Signal Transduction Membrane Protein Proteolysis	RNA Interference Pre-miRNA Processing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Posttranscriptional Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Silencing By MiRNA Targeting Of MRNA For Destruction Involved In RNA Interference Cellular Response To DsRNA Regulation Of Gene Expression Posttranscriptional Gene Silencing Gene Expression Production Of SiRNA Involved In RNA Interference Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Viral Process Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Gene Silencing By RNA Glial Cell Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To DsRNA Regulation Of Viral Genome Replication Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA 3'-end Processing Gene Silencing Regulation Of Translation Viral Process Regulation Of Metabolic Process Regulation Of MRNA 3'-end Processing ER-nucleus Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		alveolar concomitant contact downregulates elucidated endogenous fully heated hinder il interference ip kappab loads macrophages mononuclear mtb mycobacterium p65 recruitment repressing repressive repressor robust serves synthesis tb thp understood	1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Difference) ?		alveolar concomitant contact downregulates elucidated endogenous fully heated hinder il interference ip kappab loads macrophages mononuclear mtb mycobacterium p65 recruitment repressing repressive repressor robust serves synthesis tb thp understood	1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Intersection) ?