NKRF and KIFC1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		NKRF	KIFC1
Description		NFKB repressing factor	kinesin family member C1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Cytoplasm Endosome Early Endosome Centrosome Microtubule Organizing Center Spindle Cytoskeleton Kinesin Complex Microtubule Membrane Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific ATPase Activator Activity Nucleic Acid Binding DNA Binding RNA Binding Protein Binding	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Sister Chromatid Segregation Microtubule-based Movement Mitotic Metaphase Chromosome Alignment Spermatogenesis Cell Division Mitotic Spindle Assembly
Pathways			COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		16 interacting genes: ADARB1 DHX15 DHX58 FILNC1 HMOX2 KIFC1 NFKB1 NFKB2 PRKN PRKRA REL RELA STAU1 TARBP2 USP7 ZNF346	3 interacting genes: APP CEBPA NKRF
Entrez ID		55922	3833
HPRD ID		02341	18798
Ensembl ID		ENSG00000186416	ENSG00000237649
Uniprot IDs		A0AAG2UWQ9 A3F769 O15226	A0A024RCS7 Q9BW19
PDB IDs		6SH6 6SH7	5WDH
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Gene Expression Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Virus Antiviral Innate Immune Response NF-kappaB P50/p65 Complex Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Viral Genome Replication I-kappaB/NF-kappaB Complex Immune Response Defense Response To Virus NF-kappaB Complex Response To External Biotic Stimulus Immune System Process Response To Stress Response To Oxidative Stress Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nicotine Enzyme Binding RISC-loading Complex SiRNA Processing Positive Regulation Of Viral Process Pre-miRNA Binding Response To Other Organism Negative Regulation Of Metabolic Process Cellular Response To Oxidative Stress RISC Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process SiRNA Binding Regulation Of Viral Genome Replication Negative Regulation Of Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Biosynthetic Process Actinin Binding Pre-miRNA Processing Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Regulatory NcRNA Processing Cellular Response To Angiotensin Cellular Response To Interleukin-6 Cellular Response To Chemical Stress Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Viral Life Cycle Response To Interleukin-6 Negative Regulation Of Phosphorylation	Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Negative Regulation Of DNA-templated Transcription Lipoprotein Particle Memory Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Positive Regulation Of Transcription By RNA Polymerase II CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Negative Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Learning Or Memory Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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