MPP2 and LIN7A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		MPP2	LIN7A
Description		MAGUK p55 scaffold protein 2	lin-7 cell polarity scaffold A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Dendrite Membrane Cell Projection Dendritic Spine Dendritic Shaft Organelle Synapse	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity L27 Domain Binding
	Biological Process	Protein Homooligomerization Excitatory Postsynaptic Potential Long-term Synaptic Potentiation	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly
Pathways			Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Cognitive function ( 24684796)	Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)
Interacting Genes		6 interacting genes: CSNK2B DLG1 ERBIN LIN7A LIN7C PLK1	25 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 VANGL2 ZYX
Entrez ID		4355	8825
HPRD ID		02837	04542
Ensembl ID		ENSG00000108852	ENSG00000111052
Uniprot IDs		A0A0A0MRU0 A0A0C4DH75 B4DRL7 B4DZ84 D3DX48 D3DX49 Q14168	O14910
PDB IDs		2E7K
Enriched GO Terms of Interacting Partners?		L27 Domain Binding MPP7-DLG1-LIN7 Complex Basolateral Plasma Membrane Establishment Of Organelle Localization Anchoring Junction Postsynaptic Density Membrane Regulation Of Synaptic Assembly At Neuromuscular Junction Bicellular Tight Junction Organelle Localization Cell-cell Junction Protein-macromolecule Adaptor Activity Intracellular Protein Localization Synaptic Vesicle Transport Neurotransmitter Secretion Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Morphogenesis Of An Epithelium Establishment Or Maintenance Of Apical/basal Cell Polarity Tissue Morphogenesis Cytoskeletal Protein Binding Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Establishment Of Protein Localization Basement Membrane Neurotransmitter Transport Establishment Of Vesicle Localization Glutamatergic Synapse Synaptonemal Complex Disassembly Golgi Inheritance Basal Protein Localization Vesicle Localization Establishment Of Localization In Cell Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Structural Constituent Of Postsynaptic Density ErbB-2 Class Receptor Binding Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Mitotic Cell Cycle Phase Transition Lateral Loop Spindle Organization Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Synapse Assembly Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Release From Viral Latency Maintenance Of Postsynaptic Density Structure Myelin Sheath Abaxonal Region Homologous Chromosome Segregation Female Meiosis Chromosome Segregation	Cell-cell Junction Adherens Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Excitatory Postsynaptic Potential Protein Localization To Cell Junction Plasma Membrane Regulation Of Synaptic Plasticity Postsynaptic Density Membrane Modulation Of Excitatory Postsynaptic Potential Basolateral Plasma Membrane Postsynaptic Density Protein Localization To Synapse Synaptic Membrane Dendritic Spine Modulation Of Chemical Synaptic Transmission Neuromuscular Junction PDZ Domain Binding Cellular Component Assembly Neuron Projection Protein Tetramerization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Presynapse Organelle Cell Adhesion Regulation Of Nervous System Process Dendritic Shaft Protein Complex Oligomerization Ligand-gated Ion Channel Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Cell Projection Receptor Localization To Synapse Receptor Clustering Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization GMP Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Intracellular Protein Localization Trans-synaptic Signaling GDP Metabolic Process Synaptic Signaling Juxtaparanode Region Of Axon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Acetylcholine Receptor Binding
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