ZNF282 and MAPKAPK5

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF282	MAPKAPK5
Gene Name		zinc finger protein 282	mitogen-activated protein kinase-activated protein kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Zinc Ion Binding	P53 Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	MAPK Cascade Activation Of MAPK Activity Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Protein Autophosphorylation Stress-induced Premature Senescence
Pathways		Generic Transcription Pathway	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MAPKAPK5 PIK3CG PKN1	28 interactors: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576
Entrez ID		8427	8550
HPRD ID		04549	09467
Ensembl ID		ENSG00000170265	ENSG00000089022
Uniprot IDs		B4DRI5 Q9UDV7	Q8IW41
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Activation Of MAPK Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Phosphorus Metabolic Process MAPK Cascade Positive Regulation Of Catalytic Activity Natural Killer Cell Chemotaxis Activation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Signal Transduction By Phosphorylation Negative Regulation Of Triglyceride Catabolic Process Neutrophil Extravasation Phosphorylation Intracellular Signal Transduction Respiratory Burst Involved In Defense Response Negative Regulation Of Cardiac Muscle Contraction Regulation Of Cellular Protein Metabolic Process Histone H3-T11 Phosphorylation Regulation Of Protein Metabolic Process Negative Regulation Of Striated Muscle Contraction Secretory Granule Localization Regulation Of Catalytic Activity T Cell Chemotaxis Positive Regulation Of Cellular Metabolic Process Stress-induced Premature Senescence Negative Regulation Of Fibroblast Apoptotic Process Respiratory Burst Regulation Of Signal Transduction Dendritic Cell Chemotaxis Phosphate-containing Compound Metabolic Process Lymphocyte Chemotaxis T Cell Migration	MAPK Cascade Signal Transduction By Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Regulation Of Innate Immune Response Response To Organic Substance Response To Stress Gene Expression Cellular Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Protein Phosphorylation Signaling Phosphate-containing Compound Metabolic Process Cell Cycle Cell Communication Ras Protein Signal Transduction Innate Immune Response Signal Transduction Mitochondrion Organization Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Apoptotic Mitochondrial Changes Defense Response Response To Toxic Substance Cellular Response To Stimulus Response To Stimulus
Tagcloud ?			acids amino blot designated encodes erk gst homology identities jnk jun kinase light mitogen myosin northern novel nucleotide p38 phosphorylate phosphorylated recombinant sequence shares substrate wide
Tagcloud (Difference) ?			acids amino blot designated encodes erk gst homology identities jnk jun kinase light mitogen myosin northern novel nucleotide p38 phosphorylate phosphorylated recombinant sequence shares substrate wide
Tagcloud (Intersection) ?