NEUROD2 and RCAN1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		NEUROD2	RCAN1
Description		neuronal differentiation 2	regulator of calcineurin 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding Protein Phosphatase Inhibitor Activity Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Identical Protein Binding
	Biological Process	Behavioral Fear Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Associative Learning Protein Ubiquitination Cerebellar Cortex Development Cell Differentiation Positive Regulation Of Synaptic Plasticity Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Synapse Maturation Negative Regulation Of Synapse Maturation	Response To Ischemia Response To Stress Response To Oxidative Stress Skeletal Muscle Tissue Development Short-term Memory Response To Mechanical Stimulus Calcium-mediated Signaling Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Estrogen Skeletal Muscle Fiber Development Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways
Drugs			Dipyridamole
Diseases
GWAS		Asthma ( 31619474 31959851) Mean corpuscular hemoglobin ( 27863252) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Triglyceride levels ( 30108155) Ulcerative colitis ( 20228799)	Cancer ( 29299148) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		8 interacting genes: ERG GRSF1 HUNK PKN1 RCAN1 TIAM1 TK1 UBASH3A	22 interacting genes: APP BTRC CXXC5 E2F3 GSK3B MAP3K3 MAPK3 NEUROD2 PICK1 PPP3CA PPP3CB PPP3R1 PRDM4 PTPRD SF3A2 SOX10 SOX9 SPARCL1 USP22 UXT ZNF292 ZNF350
Entrez ID		4761	1827
HPRD ID		03429	04226
Ensembl ID		ENSG00000171532	ENSG00000159200
Uniprot IDs		Q15784	B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9
PDB IDs			6UUQ
Enriched GO Terms of Interacting Partners?			Regulation Of Calcium-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Regulation Of Transcription By RNA Polymerase II Glial Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Protein Serine/threonine Phosphatase Complex Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Glutamatergic Synapse Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Signaling Cassette Cell Development Regulation Of Endocytosis Positive Regulation Of Calcium Ion Import Protein Dimerization Activity Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Monoatomic Ion Transport Regulation Of Vesicle-mediated Transport Calmodulin-dependent Protein Phosphatase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport
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