VIMP and VCP

Number of citations of the paper that reports this interaction (PMID 15215856)
230

Data Source:
HPRD (in vivo)

		VIMP	VCP
Gene Name		VCP-interacting membrane protein	valosin containing protein
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Protein Binding Selenium Binding Antioxidant Activity Enzyme Binding	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity
Pathways			HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DERL1 KPNB1 SAA1 SRPK2 VCP	72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B
Entrez ID		55829	7415
HPRD ID		12133	03013
Ensembl ID		ENSG00000131871	ENSG00000165280
Uniprot IDs		Q6GYA4 Q9BQE4	P55072 Q96IF9
PDB IDs		2Q2F	3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Retrograde Protein Transport, ER To Cytosol Intracellular Transport Of Virus ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Nuclear Speck Organization Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Regulation Of Viral Process Cellular Macromolecule Catabolic Process Response To Endoplasmic Reticulum Stress Intracellular Protein Transport Viral Life Cycle Intracellular Transport Of Viral Protein In Host Cell Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Deubiquitination Protein Hexamerization Ribosomal Protein Import Into Nucleus Cellular Protein Localization Cellular Response To Stimulus Protein Transport Response To Stress Aggresome Assembly Establishment Of Protein Localization Translesion Synthesis Intracellular Transport Lymphocyte Chemotaxis Macrophage Chemotaxis Catabolic Process Apoptotic DNA Fragmentation Positive Regulation Of Interleukin-1 Secretion Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance NLS-bearing Protein Import Into Nucleus Modification-dependent Protein Catabolic Process Postreplication Repair Positive Regulation Of Viral Genome Replication Protein Localization Response To Stimulus Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Destabilization Establishment Of Localization In Cell Cellular Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling
Tagcloud ?		alpha1 antitrypsin assumed bip calumin cholera counteract cytoprotective degradations derlin die dislocation droplet e9 endoderm erad hek homozygous immunoprecipitated lethality misfolded overload p97 pointing ribosomes sac sacs seemed yolk	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Difference) ?		alpha1 antitrypsin assumed bip calumin cholera counteract cytoprotective degradations derlin die dislocation droplet e9 endoderm erad hek homozygous immunoprecipitated lethality misfolded overload p97 pointing ribosomes sac sacs seemed yolk	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Intersection) ?