VIMP and SAA1

Number of citations of the paper that reports this interaction (PMID 12031974)
22

Data Source:
HPRD (in vitro, two hybrid)

		VIMP	SAA1
Gene Name		VCP-interacting membrane protein	serum amyloid A1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle	Extracellular Region High-density Lipoprotein Particle Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Receptor Activity Protein Binding Selenium Binding Antioxidant Activity Enzyme Binding	G-protein Coupled Receptor Binding Heparin Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Receptor-mediated Endocytosis Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response
Pathways			G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Formyl peptide receptors bind formyl peptides and many other ligands DEx/H-box helicases activate type I IFN and inflammatory cytokines production Amyloids Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Peptide ligand-binding receptors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane G alpha (i) signalling events Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA GPCR ligand binding MyD88-independent cascade G alpha (q) signalling events Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways GPCR downstream signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRAF6 mediated NF-kB activation Scavenging by Class B Receptors TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Amyloid A Levels ( 21124955)
Protein-Protein Interactions		5 interactors: DERL1 KPNB1 SAA1 SRPK2 VCP	8 interactors: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 LAMA1 VIMP VKORC1
Entrez ID		55829	6288
HPRD ID		12133	00097
Ensembl ID		ENSG00000131871	ENSG00000173432
Uniprot IDs		Q6GYA4 Q9BQE4	P0DJI8
PDB IDs		2Q2F
Enriched GO Terms of Interacting Partners?		Retrograde Protein Transport, ER To Cytosol Intracellular Transport Of Virus ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Nuclear Speck Organization Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Regulation Of Viral Process Cellular Macromolecule Catabolic Process Response To Endoplasmic Reticulum Stress Intracellular Protein Transport Viral Life Cycle Intracellular Transport Of Viral Protein In Host Cell Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Deubiquitination Protein Hexamerization Ribosomal Protein Import Into Nucleus Cellular Protein Localization Cellular Response To Stimulus Protein Transport Response To Stress Aggresome Assembly Establishment Of Protein Localization Translesion Synthesis Intracellular Transport Lymphocyte Chemotaxis Macrophage Chemotaxis Catabolic Process Apoptotic DNA Fragmentation Positive Regulation Of Interleukin-1 Secretion Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance NLS-bearing Protein Import Into Nucleus Modification-dependent Protein Catabolic Process Postreplication Repair Positive Regulation Of Viral Genome Replication Protein Localization Response To Stimulus Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Destabilization Establishment Of Localization In Cell Cellular Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death	Collagen Catabolic Process Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Retinal Blood Vessel Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Retina Vasculature Morphogenesis In Camera-type Eye Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Retina Vasculature Development In Camera-type Eye Generation Of Neurons Neurogenesis Catabolic Process Cell Development Renal System Development Glomerulus Development Response To Stimulus Urogenital System Development Blood Vessel Morphogenesis Negative Regulation Of Angiogenesis Regulation Of Nitric Oxide Metabolic Process Nervous System Development Anatomical Structure Morphogenesis Blood Vessel Development Vasculature Development System Development Endothelial Cell Apoptotic Process Nephron Development Multicellular Organismal Development Organ Development Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Tagcloud ?		alpha1 antitrypsin assumed bip calumin cholera counteract cytoprotective degradations derlin die dislocation droplet e9 endoderm erad hek homozygous immunoprecipitated lethality misfolded overload p97 pointing ribosomes sac sacs seemed yolk	10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll
Tagcloud (Difference) ?		alpha1 antitrypsin assumed bip calumin cholera counteract cytoprotective degradations derlin die dislocation droplet e9 endoderm erad hek homozygous immunoprecipitated lethality misfolded overload p97 pointing ribosomes sac sacs seemed yolk	10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll
Tagcloud (Intersection) ?