SELENOS and SAA1

Number of citations of the paper that reports this interaction (PubMedID 12031974)
0

Data Source:
HPRD (two hybrid, in vitro)

		SELENOS	SAA1
Description		selenoprotein S	serum amyloid A1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding	G Protein-coupled Receptor Binding Heparin Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis Intracellular Protein Transport ER Overload Response Response To Glucose Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress ERAD Pathway Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of D-glucose Import Negative Regulation Of Inflammatory Response Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Positive Regulation Of Cytokine Production Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation
Drugs
Diseases
GWAS			Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576) Rosacea symptom severity ( 29771307)
Interacting Genes		9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP	9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1
Entrez ID		55829	6288
HPRD ID		12133	00097
Ensembl ID		ENSG00000131871	ENSG00000173432
Uniprot IDs		Q6GYA4 Q9BQE4	P0DJI8
PDB IDs		2Q2F 5KIU 5KIY 6DO4	4IP8 4IP9 6MST 7ZKY
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Spliceosomal Complex Assembly Derlin-1 Retrotranslocation Complex Cellular Response To Misfolded Protein Response To Misfolded Protein Protein-RNA Complex Assembly Retrograde Protein Transport, ER To Cytosol MHC Class I Protein Binding Ubiquitin-specific Protease Binding High-density Lipoprotein Particle Regulation Of MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Topologically Incorrect Protein	Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Retinal Blood Vessel Morphogenesis Extracellular Structure Organization Extracellular Matrix Organization Retina Vasculature Morphogenesis In Camera-type Eye Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Signal Transduction Glucagon-like Peptide 1 Receptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity N-formyl Peptide Receptor Activity Derlin-1-VIMP Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Vessel Morphogenesis Glucagon Receptor Activity Laminin-1 Complex Laminin-3 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Scavenger Receptor Binding Laminin Complex Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Multicellular Organismal Process Response To Psychosocial Stress Morphogenesis Of A Branching Epithelium Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Glycosphingolipid Binding Morphogenesis Of A Branching Structure Extracellular Region Negative Regulation Of Macrophage Apoptotic Process Complement Receptor Activity Cellular Response To Peptide Hormone Stimulus Post-translational Protein Targeting To Membrane, Translocation Derlin-1 Retrotranslocation Complex Regulation Of Basement Membrane Organization Molecular Adaptor Activity Negative Regulation Of Glycogen Biosynthetic Process Protein Complex Involved In Cell-matrix Adhesion
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