PAG1 and HTRA2

Number of citations of the paper that reports this interaction (PubMedID 16413409)
0

Data Source:
HPRD (two hybrid, in vitro)

		PAG1	HTRA2
Description		phosphoprotein membrane anchor with glycosphingolipid microdomains 1	HtrA serine peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Membrane Raft	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex
	Molecular Function	Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Adaptive Immune Response Immune System Process Signal Transduction Intracellular Signal Transduction Regulation Of T Cell Activation Negative Regulation Of T Cell Activation	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains	Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Aspartate aminotransferase levels ( 33547301) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Health literacy ( 31250787) Serum total protein levels ( 23022100)
Interacting Genes		17 interacting genes: ABL1 CSK FYN GLS2 GRB2 HTRA2 LCK LCP2 LYN NHERF1 PTPN11 PTPN6 RASA1 SHC1 SYK VAV1 ZAP70	41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP
Entrez ID		55824	27429
HPRD ID		05772	05919
Ensembl ID		ENSG00000076641	ENSG00000115317
Uniprot IDs		Q9NWQ8	A0A384MDW9 A0A8Q3SIX7 O43464
PDB IDs			1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Fc-gamma Receptor Signaling Pathway Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Ephrin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Lymphocyte Activation T Cell Activation Regulation Of Signal Transduction Cell-cell Junction Positive Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Immune Effector Process Regulation Of Immune System Process	Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process
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