PAG1 and SYK

Number of citations of the paper that reports this interaction (PMID 10790433)
107

Data Source:
HPRD (in vitro)

		PAG1	SYK
Gene Name		phosphoprotein membrane anchor with glycosphingolipid microdomains 1	spleen tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Membrane Raft	Nucleus Cytoplasm Cytosol Plasma Membrane B Cell Receptor Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Early Phagosome T Cell Receptor Complex Protein Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH2 Domain Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Integrin Binding Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Negative Regulation Of T Cell Activation	Angiogenesis Lymph Vessel Development Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Serotonin Secretion By Platelet Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Blood Coagulation Cell Proliferation Organ Morphogenesis Regulation Of Platelet Activation Viral Process Leukotriene Biosynthetic Process Platelet Activation Neutrophil Chemotaxis Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Transcription Factor Import Into Nucleus Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Regulation Of Arachidonic Acid Secretion Regulation Of Platelet Aggregation
Pathways		Signaling by EGFR TCR signaling GAB1 signalosome Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Signaling by the B Cell Receptor (BCR) FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) DAP12 signaling Regulation of signaling by CBL Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System DAP12 interactions Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade Interleukin-2 signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs			Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic Acid
Diseases
GWAS		Serum total protein level ( 23022100)	Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)
Protein-Protein Interactions		17 interactors: ABL1 CSK FYN GLS2 GRB2 HTRA2 LCK LCP2 LYN PTPN11 PTPN6 RASA1 SHC1 SLC9A3R1 SYK VAV1 ZAP70	98 interactors: APP BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CRKL CSF2RB CSF3R CTTN DBNL DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HNRNPU IL15RA IL2RB ITGB2 JAK1 LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2
Entrez ID		55824	6850
HPRD ID		05772	02514
Ensembl ID		ENSG00000076641	ENSG00000165025
Uniprot IDs		Q9NWQ8	A8K4G2 P43405
PDB IDs			1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Immune Response-activating Cell Surface Receptor Signaling Pathway Hemostasis Enzyme Linked Receptor Protein Signaling Pathway Platelet Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Innate Immune Response T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Regulation Of Body Fluid Levels Peptidyl-tyrosine Autophosphorylation Wound Healing Regulation Of Immune Response Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cell Activation Response To Wounding Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cell Migration Regulation Of Lymphocyte Activation Cell Motility Positive Regulation Of Immune System Process Locomotion Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Immune Response Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Defense Response Regulation Of Cell Activation Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Intracellular Signal Transduction	Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Defense Response Fc Receptor Signaling Pathway Immune Response Signal Transduction Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Positive Regulation Of Immune Response Signaling Positive Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Neurotrophin Signaling Pathway Intracellular Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus ERBB Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Response To Wounding Blood Coagulation Hemostasis Wound Healing Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Leukocyte Activation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Platelet Activation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		adaptor cbp cpg deacetylase egf epigenetic h4 harboring hdac hdac1 hypomethylation inactivation inhibiting inversely islands mapk mek modifications oncogenic pi3k restored src subset suppressed suppressor transformation transformed transmembrane trimethylation	belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine tyrosines ut7
Tagcloud (Difference) ?		adaptor cbp cpg deacetylase egf epigenetic h4 harboring hdac hdac1 hypomethylation inactivation inhibiting inversely islands mapk mek modifications oncogenic pi3k restored subset suppressed suppressor transformation transformed transmembrane trimethylation	belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 tandem tyrosine tyrosines ut7
Tagcloud (Intersection) ?		src