PAG1

Description		phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Membrane Raft
	Molecular Function	Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Adaptive Immune Response Immune System Process Signal Transduction Intracellular Signal Transduction Regulation Of T Cell Activation Negative Regulation Of T Cell Activation
Pathways		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Health literacy ( 31250787) Serum total protein levels ( 23022100)
Interacting Genes		17 interacting genes: ABL1 CSK FYN GLS2 GRB2 HTRA2 LCK LCP2 LYN NHERF1 PTPN11 PTPN6 RASA1 SHC1 SYK VAV1 ZAP70
Entrez ID		55824
HPRD ID		05772
Ensembl ID		ENSG00000076641
Uniprot IDs		Q9NWQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Fc-gamma Receptor Signaling Pathway Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Ephrin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Lymphocyte Activation T Cell Activation Regulation Of Signal Transduction Cell-cell Junction Positive Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Immune Effector Process Regulation Of Immune System Process
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