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PRKCD and IKBKB
Number of citations of the paper that reports this interaction (PubMedID
10022904
)
40
Data Source:
BioGRID
(enzymatic study)
PRKCD
IKBKB
Description
protein kinase C delta
inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Endomembrane System
Membrane
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Zinc Ion Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Biological Process
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Immunoglobulin Mediated Immune Response
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Termination Of Signal Transduction
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of MRNA Stability
Post-translational Protein Modification
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Protein Stabilization
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Cellular Response To Hydrogen Peroxide
Protein Kinase C Signaling
Cellular Response To Fatty Acid
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Pathways
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
KEAP1-NFE2L2 pathway
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
Tamoxifen
Staurosporine
Dequalinium
13-Acetylphorbol
Ingenol mebutate
Benzoyl peroxide
Fostamatinib
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
GWAS
A body shape index (
34021172
)
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
121 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTOV1
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
Entrez ID
5580
3551
HPRD ID
01501
04462
Ensembl ID
ENSG00000163932
ENSG00000104365
Uniprot IDs
B4DFV1
Q05655
A0A499FJS7
G3V105
O14920
PDB IDs
1YRK
2YUU
3BRT
3BRV
4E3C
4KIK
8OMV
Enriched GO Terms of Interacting Partners
?
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Focal Adhesion
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Developmental Process
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signaling Cassette
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
Regulation Of Apoptotic Process
Regulation Of Transport
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Programmed Cell Death
Positive Regulation Of Locomotion
Regulation Of Metabolic Process
Regulation Of Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cellular Component Organization
Regulation Of Locomotion
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Protein Localization
Positive Regulation Of Developmental Process
Regulation Of Biological Quality
Regulation Of Cell Adhesion
Response To Peptide Hormone
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
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Tagcloud (Intersection)
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