PRKCD and NFE2L2

Number of citations of the paper that reports this interaction (PMID 12198130)
120

Data Source:
HPRD (in vitro)

		PRKCD	NFE2L2
Gene Name		protein kinase C, delta	nuclear factor, erythroid 2-like 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Insulin Receptor Substrate Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Gene Expression Regulation Of Receptor Activity Immunoglobulin Mediated Immune Response Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Binding Interleukin-10 Production Interleukin-12 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Dephosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Defense Response To Bacterium Negative Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Transcription From RNA Polymerase II Promoter Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Interferon gamma signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF Calmodulin induced events Regulation of mRNA stability by proteins that bind AU-rich elements Apoptotic cleavage of cellular proteins DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer Platelet activation, signaling and aggregation G alpha (q) signalling events HuR stabilizes mRNA DAG and IP3 signaling VEGFA-VEGFR2 Pathway CaM pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Signalling by NGF PLC beta mediated events Interferon Signaling Apoptotic execution phase Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Ulcerative colitis ( 23128233) Ventricular conduction ( 21076409)
Protein-Protein Interactions		118 interactors: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 ADRBK1 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GNB2L1 GRM5 GSK3A HABP4 HDAC5 HIST1H1A HIST1H1B HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP VHL YWHAB YWHAG YWHAZ	35 interactors: ATF4 BPTF CASP1 CASP3 CHD6 COPS7A CREB3 CREBBP DYT10 EIF2AK3 GSK3B JUN JUND KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 NCOR2 NFE2 NFE2L3 PMF1 PPARG PRKCA PRKCD PRKCG PRKCH PRKCQ RBMX SUMO1 TNNT1 TRIM24 UBE2E2 WAC
Entrez ID		5580	4780
HPRD ID		01501	02732
Ensembl ID		ENSG00000163932	ENSG00000116044
Uniprot IDs		Q05655	Q16236
PDB IDs		1YRK 2YUU	2FLU 2LZ1 3ZGC
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Cellular Response To Stimulus Cellular Response To Peptide Hormone Stimulus Defense Response Response To Stress Cellular Response To Organonitrogen Compound Response To Stimulus Platelet Activation Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Immune System Process Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Peptide Response To Hormone Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Innate Immune Response Regulation Of Signaling Response To Peptide Hormone Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Wound Healing Cell Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Hemostasis Positive Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Modification Process Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Fc Receptor Signaling Pathway Immune Response Response To Insulin	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Response To Stimulus Transcription From RNA Polymerase II Promoter Response To Wounding Cellular Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Blood Coagulation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Hemostasis Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Stimulus Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct
Tagcloud (Intersection) ?