PRKCD and ACTA2

Number of citations: 0 (PubMedID 10628374)
Data Source: HPRD (in vitro)

		PRKCD	ACTA2
Name		protein kinase C delta	actin alpha 2, smooth muscle
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Endomembrane System Membrane Nuclear Matrix Azurophil Granule Lumen Endolysosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Stress Fiber Basement Membrane Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Motile Cilium Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Protein Phosphorylation Apoptotic Process DNA Damage Response Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Immunoglobulin Mediated Immune Response Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Termination Of Signal Transduction Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Superoxide Anion Generation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Glial Cell Apoptotic Process Cellular Response To UV Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of MRNA Stability Post-translational Protein Modification Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Filopodium Assembly Cell Chemotaxis Cellular Response To Hydrogen Peroxide Protein Kinase C Signaling Cellular Response To Fatty Acid Cellular Response To Hydroperoxide Negative Regulation Of Platelet Aggregation Cellular Senescence Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Phospholipid Scramblase Activity Cellular Response To Angiotensin Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Juxtaglomerular Apparatus Development Glomerular Mesangial Cell Development Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Apoptotic cleavage of cellular proteins Calmodulin induced events Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events HuR (ELAVL1) binds and stabilizes mRNA VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Interferon gamma signaling KEAP1-NFE2L2 pathway	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		Tamoxifen Staurosporine Dequalinium 13-Acetylphorbol Ingenol mebutate Benzoyl peroxide Fostamatinib	Phenethyl Isothiocyanate
Diseases		None	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		A body shape index ( 34021172 ) Bipolar disorder ( 21926972 ) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083 ) Ulcerative colitis ( 23128233 ) Waist circumference adjusted for body mass index ( 28552196 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Arthritis (juvenile idiopathic) ( 33106285 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic lymphocytic leukemia ( 23770605 26956414 ) Immunoglobulin A ( 20694011 ) Lymphocyte percentage of white cells ( 32888494 ) Pulse pressure ( 30578418 ) Selective IgA deficiency ( 27723758 )
Interacting Genes		121 interacting genes: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GRK2 GRM5 GSK3A H1-1 H1-5 HABP4 HDAC5 HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NOTCH1 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTOV1 PTPN22 PTPN6 PTPRA RAC1 RACK1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SPRY2 SQSTM1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP YWHAB YWHAG YWHAZ	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		5580	59
HPRD ID		01501	00031
Ensembl ID		ENSG00000163932	ENSG00000107796
Uniprot IDs		B4DFV1 Q05655	A0AAQ5BGG7 A0AAQ5BGI6 D2JYH4 P62736
PDB IDs		1YRK 2YUU	Not available
GO Terms Enriched among Interactors		Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Regulation Of Apoptotic Process Regulation Of Transport Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Programmed Cell Death Positive Regulation Of Locomotion Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Locomotion Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Localization Positive Regulation Of Developmental Process Regulation Of Biological Quality Regulation Of Cell Adhesion Response To Peptide Hormone Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Protein Stabilization Regulation Of Biological Quality Extracellular Exosome Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Protein Localization Actin Binding Regulation Of Protein Stability Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex N-terminal Protein Amino Acid Acetylation Regulation Of Telomerase RNA Localization To Cajal Body Peptidyl-lysine Acetylation Cellular Response To UV Regulation Of Cell Adhesion Regulation Of Organelle Organization Regulation Of Cellular Response To Heat Regulation Of Actin Filament Organization Regulation Of Defense Response Intracellular Signaling Cassette Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Cellular Response To Light Stimulus Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Actin Filament Polymerization Histone Acetyltransferase Complex Regulation Of Cell-matrix Adhesion Protein-lysine-acetyltransferase Activity Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Neutrophil Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Focal Adhesion Assembly Binding Of Sperm To Zona Pellucida Histone Acetyltransferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Acetylation