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PRKCD and LCK
Number of citations of the paper that reports this interaction (PubMedID
11381116
)
37
Data Source:
HPRD
(in vitro)
PRKCD
LCK
Description
protein kinase C delta
LCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Endomembrane System
Membrane
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Pericentriolar Material
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Membrane Raft
Extracellular Exosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Zinc Ion Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
ATPase Binding
Protein Antigen Binding
Biological Process
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Immunoglobulin Mediated Immune Response
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Termination Of Signal Transduction
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of MRNA Stability
Post-translational Protein Modification
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Protein Stabilization
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Cellular Response To Hydrogen Peroxide
Protein Kinase C Signaling
Cellular Response To Fatty Acid
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Intracellular Zinc Ion Homeostasis
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Xenobiotic Stimulus
Positive Regulation Of Gene Expression
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Platelet Activation
T Cell Differentiation
T Cell Costimulation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Gamma-delta T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Multicellular Organismal Process
Regulation Of Lymphocyte Activation
CD27 Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
KEAP1-NFE2L2 pathway
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
Co-inhibition by PD-1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOH GTPase cycle
Interleukin-2 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Drugs
Tamoxifen
Staurosporine
Dequalinium
13-Acetylphorbol
Ingenol mebutate
Benzoyl peroxide
Fostamatinib
Dasatinib
AP-22408
Staurosporine
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
{4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
Phosphoaminophosphonic Acid-Adenylate Ester
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
Ponatinib
Nintedanib
Fostamatinib
Zanubrutinib
Zotiraciclib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
A body shape index (
34021172
)
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Multiple sclerosis (
31604244
)
Interacting Genes
121 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTOV1
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
142 interacting genes:
ACP1
ADAM15
AJUBA
AR
ARHGAP17
ASB9
AXL
BCAR1
BRCA1
C1QTNF2
CBL
CCR5
CD2
CD247
CD28
CD38
CD3E
CD4
CD44
CD48
CD5
CD55
CD79A
CD79B
CD8A
CDC25C
CDC42
CDC45
CDKAL1
CIMIP2B
CSF2RB
CSF3R
CSK
CSNK2B
CTDSP1
CTLA4
CTNND2
DAPP1
DEF6
DLG1
DOK1
DOK2
DOK3
EGFR
ERBB2
ERBB3
ERBB4
ESR1
ESR2
EZR
FAM174A
FAS
FASLG
FCGR3A
FYN
G3BP1
GAB2
GATA3
GRAP
HSP90AA1
IFNAR1
IKBKG
IL2RB
ITK
JAK3
KHDRBS1
KIR2DL3
KIT
LAT
LAX1
LCP2
LIME1
LZTS2
MAPK1
MAPK3
MAPT
MED28
MET
MS4A1
MUC1
NEDD9
NFKBIA
NFKBID
NOTCH1
NR3C1
PAG1
PAK2
PECAM1
PI4KA
PIK3CA
PIK3R1
PLCG1
PLCG2
PLD2
PRKACA
PRKCA
PRKCD
PRKCQ
PTK2
PTK2B
PTPN11
PTPN22
PTPN6
PTPRC
PTPRF
PTPRH
PXN
RAF1
RASA1
RIN3
RORB
SH2B3
SH2D1A
SH2D2A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SMAD2
SMAD3
SMURF1
SOCS1
SOS1
SQSTM1
STAT1
STAT3
STAT5A
SYK
THY1
TRAT1
TRIM35
TRPV4
TUB
UBAP2
UBE3A
UHRF2
UNC119
VAV1
WAS
WASL
ZAP70
Entrez ID
5580
3932
HPRD ID
01501
01080
Ensembl ID
ENSG00000163932
ENSG00000182866
Uniprot IDs
B4DFV1
Q05655
A0A0S2Z3Y8
E9PJ92
E9PKQ8
P06239
Q573B4
PDB IDs
1YRK
2YUU
1BHF
1BHH
1CWD
1CWE
1FBZ
1H92
1IJR
1KIK
1LCJ
1LCK
1LKK
1LKL
1Q68
1Q69
1QPC
1QPD
1QPE
1QPJ
1X27
2IIM
2OF2
2OF4
2OFU
2OFV
2OG8
2PL0
2ZM1
2ZM4
2ZYB
3AC1
3AC2
3AC3
3AC4
3AC5
3AC8
3ACJ
3ACK
3AD4
3AD5
3AD6
3B2W
3BRH
3BYM
3BYO
3BYS
3BYU
3KMM
3KXZ
3LCK
3MPM
4C3F
4D8K
5MTM
5MTN
6H6A
6PDJ
8X2P
Enriched GO Terms of Interacting Partners
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Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Focal Adhesion
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Developmental Process
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signaling Cassette
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
Regulation Of Apoptotic Process
Regulation Of Transport
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Programmed Cell Death
Positive Regulation Of Locomotion
Regulation Of Metabolic Process
Regulation Of Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cellular Component Organization
Regulation Of Locomotion
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Protein Localization
Positive Regulation Of Developmental Process
Regulation Of Biological Quality
Regulation Of Cell Adhesion
Response To Peptide Hormone
Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Plasma Membrane
Intracellular Signal Transduction
T Cell Receptor Signaling Pathway
Lymphocyte Activation
Positive Regulation Of Immune Response
Leukocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Immune Response
Adaptive Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Intracellular Signaling Cassette
Regulation Of Cell Activation
Protein Kinase Binding
Regulation Of T Cell Activation
T Cell Activation
Cytokine-mediated Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Leukocyte Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Intracellular Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cellular Component Organization
Regulation Of Multicellular Organismal Process
Negative Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
ERBB Signaling Pathway
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Tagcloud (Difference)
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Tagcloud (Intersection)
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