PRKCD and NCF1

Number of citations of the paper that reports this interaction (PMID 12056906)
86

Data Source:
BioGRID (enzymatic study)

		PRKCD	NCF1
Gene Name		protein kinase C, delta	neutrophil cytosolic factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Insulin Receptor Substrate Binding Metal Ion Binding	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Gene Expression Regulation Of Receptor Activity Immunoglobulin Mediated Immune Response Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Binding Interleukin-10 Production Interleukin-12 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Dephosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Defense Response To Bacterium Negative Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Response To Yeast Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Apoptotic Process Inflammatory Response Cellular Defense Response Cell Proliferation Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Negative Regulation Of Smooth Muscle Contraction Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Interaction With Host Oxidation-reduction Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Phagosome Maturation
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Interferon gamma signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF Calmodulin induced events Regulation of mRNA stability by proteins that bind AU-rich elements Apoptotic cleavage of cellular proteins DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer Platelet activation, signaling and aggregation G alpha (q) signalling events HuR stabilizes mRNA DAG and IP3 signaling VEGFA-VEGFR2 Pathway CaM pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Signalling by NGF PLC beta mediated events Interferon Signaling Apoptotic execution phase Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Ulcerative colitis ( 23128233) Ventricular conduction ( 21076409)
Protein-Protein Interactions		118 interactors: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 ADRBK1 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GNB2L1 GRM5 GSK3A HABP4 HDAC5 HIST1H1A HIST1H1B HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP VHL YWHAB YWHAG YWHAZ	23 interactors: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PRKCA PRKCB PRKCD PRKCZ PRKDC SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		5580	653361
HPRD ID		01501
Ensembl ID		ENSG00000163932	ENSG00000158517
Uniprot IDs		Q05655	P14598
PDB IDs		1YRK 2YUU	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Cellular Response To Stimulus Cellular Response To Peptide Hormone Stimulus Defense Response Response To Stress Cellular Response To Organonitrogen Compound Response To Stimulus Platelet Activation Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Immune System Process Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Peptide Response To Hormone Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Innate Immune Response Regulation Of Signaling Response To Peptide Hormone Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Wound Healing Cell Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Hemostasis Positive Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Modification Process Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Fc Receptor Signaling Pathway Immune Response Response To Insulin	Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3-T6 Phosphorylation Platelet Activation Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Immune Response Apoptotic Signaling Pathway Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Phospholipase Activity Cell Death Regulation Of Protein Phosphorylation Death Blood Coagulation Regulation Of Cellular Protein Metabolic Process Hemostasis Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Organelle Organization Mitotic Cell Cycle Positive Regulation Of Lipase Activity Response To Interleukin-1 Innate Immune Response Regulation Of Glucose Transport Regulation Of Platelet Aggregation Regulation Of Protein Metabolic Process Muscle System Process Negative Regulation Of Glucose Transport Signaling Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
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