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SEMG2 and KLK2
Number of citations of the paper that reports this interaction (PMID
10411640
)
7
Data Source:
HPRD
(in vitro, in vivo)
SEMG2
KLK2
Gene Name
semenogelin II
kallikrein-related peptidase 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Secretory Granule
Extracellular Vesicular Exosome
Extracellular Region
Extracellular Vesicular Exosome
Molecular Function
Structural Molecule Activity
Serine-type Endopeptidase Activity
Biological Process
Sexual Reproduction
Proteolysis
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Drugs
Diseases
GWAS
PCA3 expression level (
23555189
)
Prostate-specific antigen levels (
23359319
)
Protein-Protein Interactions
7 interactors:
KLK2
KLK3
PRKAR2A
PRKCA
SEMG1
SERPINA5
TGM1
14 interactors:
A2M
APP
AR
IGFBP2
POLR2A
SEMG1
SEMG2
SERPINA3
SERPINA4
SERPINA5
SERPINB6
SERPINC1
SERPINE1
SERPINF2
Entrez ID
6407
3817
HPRD ID
01642
01006
Ensembl ID
ENSG00000124157
ENSG00000167751
Uniprot IDs
Q02383
B4DU77
P20151
PDB IDs
Enriched GO Terms of Interacting Partners
?
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Response To Wounding
Activation Of Phospholipase C Activity
Positive Regulation Of Phospholipase C Activity
Extracellular Matrix Organization
Extracellular Structure Organization
Positive Regulation Of Phospholipase Activity
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Positive Regulation Of Dense Core Granule Biogenesis
Extracellular Matrix Disassembly
Positive Regulation Of Inflammatory Response
Regulation Of Blood Coagulation
Factor XII Activation
Cell Envelope Organization
Histone H3-T6 Phosphorylation
Regulation Of Wound Healing
Negative Regulation Of Protein Serine/threonine Kinase Activity
Energy Reserve Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Catalytic Activity
Positive Regulation Of Fibrinolysis
Negative Regulation Of Cellular Protein Metabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of Insulin Secretion
Negative Regulation Of Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Protein Kinase Activity
Regulation Of Peptide Hormone Secretion
Regulation Of Angiogenesis
Neurotrophin Signaling Pathway
Peptidyl-serine Autophosphorylation
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Kinase Activity
Regulation Of Protein Metabolic Process
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Plasminogen Activation
Regulation Of Hormone Secretion
Desmosome Assembly
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Inflammatory Response
Plasma Kallikrein-kinin Cascade
Energy Derivation By Oxidation Of Organic Compounds
Negative Regulation Of Glucose Import
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Peptidase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Regulation Of Endopeptidase Activity
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Regulation Of Peptidase Activity
Regulation Of Proteolysis
Negative Regulation Of Catalytic Activity
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Platelet Degranulation
Blood Coagulation
Hemostasis
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Body Fluid Levels
Regulation Of Protein Metabolic Process
Wound Healing
Regulation Of Catalytic Activity
Response To Wounding
Platelet Activation
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Fibrinolysis
Regulation Of Fibrinolysis
Regulation Of Blood Coagulation
Exocytosis
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Wound Healing
Reproductive Process
Transcription Initiation From RNA Polymerase II Promoter
Fibrinolysis
Positive Regulation Of Blood Coagulation
Secretion By Cell
Acute-phase Response
Positive Regulation Of Coagulation
Response To Stress
DNA-templated Transcription, Initiation
Positive Regulation Of Wound Healing
Regulation Of Metabolic Process
Secretion
Mating
Negative Regulation Of Blood Coagulation
Cell Activation
Regulation Of Inflammatory Response
Negative Regulation Of Coagulation
Negative Regulation Of Integrin Biosynthetic Process
Regulation Of Blood Coagulation, Intrinsic Pathway
Tagcloud
?
422a
akt3
circuit
differentially
dysregulated
effectors
encode
gleason
grades
kallikrein
kallikreins
klk14
klk15
klk3
klk4
micrornas
microsatellite
minisatellite
mirna
mirnas
nucleotides
pik3cg
prostate
proteases
pseudogene
repeats
share
silico
talk
Tagcloud (Difference)
?
422a
akt3
circuit
differentially
dysregulated
effectors
encode
gleason
grades
kallikrein
kallikreins
klk14
klk15
klk3
klk4
micrornas
microsatellite
minisatellite
mirna
mirnas
nucleotides
pik3cg
prostate
proteases
pseudogene
repeats
share
silico
talk
Tagcloud (Intersection)
?