SEMG2 and KLK2

Number of citations of the paper that reports this interaction (PubMedID 10411640)
0

Data Source:
HPRD (in vitro, in vivo)

		SEMG2	KLK2
Description		semenogelin 2	kallikrein related peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Extracellular Exosome	Extracellular Region Extracellular Space Secretory Granule Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Zinc Ion Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Antibacterial Humoral Response Sperm Capacitation Coagulation Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways			Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 29273806) Bipolar disorder ( 31043756) Malaria ( 31844061)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		8 interacting genes: KLK2 KLK3 PRKAR2A PRKCA PTPRF SEMG1 SERPINA5 TGM1	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		6407	3817
HPRD ID		01642	01006
Ensembl ID		ENSG00000124157	ENSG00000167751
Uniprot IDs		Q02383	A0A024R4J4 B4DU77 P20151
PDB IDs			4NFE 4NFF
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein-containing Complex Zymogen Activation Regulation Of Systemic Arterial Blood Pressure Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Chondroitin Sulfate Proteoglycan Binding Serine-type Peptidase Activity Secretory Granule Platelet Dense Tubular Network Seminal Clot Liquefaction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Cell Envelope Organization Positive Regulation Of Antibacterial Peptide Production Acrosin Binding Protein Kinase C Signaling Negative Regulation Of Receptor Binding Insemination Serine-type Endopeptidase Activity Heparin Binding Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Blood Pressure Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extracellular Space Protein Processing Positive Regulation Of Antimicrobial Humoral Response CAMP-dependent Protein Kinase Regulator Activity Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein-glutamine Gamma-glutamyltransferase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endopeptidase Activity Regulation Of Antimicrobial Humoral Response Protein Metabolic Process	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Extracellular Space Extracellular Exosome Extracellular Region Platelet Alpha Granule Lumen Extracellular Matrix Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Blood Microparticle Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Endopeptidase Inhibitor Activity Negative Regulation Of Plasminogen Activation Regulation Of Proteolysis Signaling Receptor Binding Positive Regulation Of Endopeptidase Activity Antibacterial Humoral Response Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Coagulation Platelet Alpha Granule Fibrinolysis Sperm Capacitation Defense Response To Bacterium Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Maturation Molecular Function Activator Activity Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Positive Regulation Of Chemotaxis Positive Regulation Of Coagulation Cell Maturation Regulation Of G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Heparin Binding Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Bacterium Epithelial Cell Morphogenesis Positive Regulation Of Supramolecular Fiber Organization
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