SEMG2 and SERPINA5

Number of citations of the paper that reports this interaction (PubMedID 8665956)
0

Data Source:
HPRD (in vitro)

		SEMG2	SERPINA5
Description		semenogelin 2	serpin family A member 5
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Extracellular Exosome	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Extracellular Matrix Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex
	Molecular Function	Protease Binding Protein Binding Zinc Ion Binding	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity Phosphatidylcholine Binding Acrosin Binding
	Biological Process	Antibacterial Humoral Response Sperm Capacitation Coagulation Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility	Lipid Transport Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Seminal Clot Liquefaction
Pathways			Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation
Drugs		Zinc chloride Zinc sulfate, unspecified form	Urokinase Drotrecogin alfa Tifuvirtide PPL-100
Diseases
GWAS		Asthma ( 29273806) Bipolar disorder ( 31043756) Malaria ( 31844061)	Blood protein levels ( 30072576) Serum albumin levels ( 29403010) Serum total protein levels ( 29403010)
Interacting Genes		8 interacting genes: KLK2 KLK3 PRKAR2A PRKCA PTPRF SEMG1 SERPINA5 TGM1	22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD
Entrez ID		6407	5104
HPRD ID		01642	03503
Ensembl ID		ENSG00000124157	ENSG00000188488
Uniprot IDs		Q02383	B4DDH1 P05154
PDB IDs			1LQ8 2HI9 2OL2 3DY0
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein-containing Complex Zymogen Activation Regulation Of Systemic Arterial Blood Pressure Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Chondroitin Sulfate Proteoglycan Binding Serine-type Peptidase Activity Secretory Granule Platelet Dense Tubular Network Seminal Clot Liquefaction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Cell Envelope Organization Positive Regulation Of Antibacterial Peptide Production Acrosin Binding Protein Kinase C Signaling Negative Regulation Of Receptor Binding Insemination Serine-type Endopeptidase Activity Heparin Binding Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Blood Pressure Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extracellular Space Protein Processing Positive Regulation Of Antimicrobial Humoral Response CAMP-dependent Protein Kinase Regulator Activity Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein-glutamine Gamma-glutamyltransferase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endopeptidase Activity Regulation Of Antimicrobial Humoral Response Protein Metabolic Process	Zymogen Activation Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Blood Coagulation Hemostasis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Plasminogen Activation Regulation Of Hemostasis Serine-type Peptidase Activity Serine-type Endopeptidase Activity Fibrinolysis Protein Processing Regulation Of Wound Healing Proteolysis Regulation Of Response To Wounding Regulation Of Body Fluid Levels Regulation Of Fibrinolysis Protein Maturation Peptidase Activity Extracellular Space Protein Metabolic Process Regulation Of Biological Quality Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Region Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process Protein Activation Cascade Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Hydrolase Activity External Side Of Plasma Membrane Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Protein Maturation Positive Regulation Of Wound Healing Blood Coagulation, Common Pathway Platelet Activation Platelet Alpha Granule Negative Regulation Of Protein Maturation Positive Regulation Of Vasoconstriction Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Secretory Granule Positive Regulation Of Fibrinolysis Regulation Of Protein Metabolic Process
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