SEMG2 and KLK3

Number of citations of the paper that reports this interaction (PMID 11027412)
27

Data Source:
HPRD (in vitro)

		SEMG2	KLK3
Gene Name		semenogelin II	kallikrein-related peptidase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Secretory Granule Extracellular Vesicular Exosome	Extracellular Region Nucleus Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Sexual Reproduction	Proteolysis Negative Regulation Of Angiogenesis Cellular Protein Metabolic Process
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS			PCA3 expression level ( 23555189) Prostate cancer ( 18264097) Prostate-specific antigen levels ( 21160077 23269536)
Protein-Protein Interactions		7 interactors: KLK2 KLK3 PRKAR2A PRKCA SEMG1 SERPINA5 TGM1	14 interactors: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI
Entrez ID		6407	354
HPRD ID		01642	01461
Ensembl ID		ENSG00000124157	ENSG00000142515
Uniprot IDs		Q02383	P07288 Q546G3
PDB IDs			1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Regulation Of Blood Coagulation Factor XII Activation Cell Envelope Organization Histone H3-T6 Phosphorylation Regulation Of Wound Healing Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Fibrinolysis Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Negative Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Peptide Hormone Secretion Regulation Of Angiogenesis Neurotrophin Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Plasminogen Activation Regulation Of Hormone Secretion Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Inflammatory Response Plasma Kallikrein-kinin Cascade Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Glucose Import	Platelet Degranulation Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Exocytosis Response To Wounding Acute-phase Response Negative Regulation Of Catalytic Activity Reproductive Process Regulation Of Cellular Protein Metabolic Process Secretion By Cell Regulation Of Protein Metabolic Process Acute Inflammatory Response Regulation Of Catalytic Activity Extracellular Matrix Disassembly Secretion Cell Activation Negative Regulation Of Cellular Metabolic Process Tissue Homeostasis Multicellular Organismal Homeostasis Female Pregnancy Response To Methanol Nipple Sheath Formation Mammary Gland Bud Elongation Vesicle-mediated Transport Endoderm Development Extracellular Matrix Organization Extracellular Structure Organization Maintenance Of Mitochondrion Location Erythropoietin-mediated Signaling Pathway Response To Triglyceride Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Inflammatory Response Response To Platinum Ion Mononuclear Cell Migration Hemolysis By Symbiont Of Host Erythrocytes
Tagcloud ?			ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Difference) ?			ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Intersection) ?