SEMG2 and KLK3

Number of citations of the paper that reports this interaction (PubMedID 24981860)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SEMG2	KLK3
Description		semenogelin 2	kallikrein related peptidase 3
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Zinc Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
	Biological Process	Antibacterial Humoral Response Sperm Capacitation Coagulation Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility	Positive Regulation Of Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Zinc chloride Zinc sulfate, unspecified form	Mifepristone Metribolone Cyproterone acetate Gallium Ga-68 gozetotide Lutetium Lu-177 vipivotide tetraxetan
Diseases
GWAS		Asthma ( 29273806) Bipolar disorder ( 31043756) Malaria ( 31844061)	Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 24753544 26034056 31562322 34012061) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 23269536 24919509 25434496 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)
Interacting Genes		8 interacting genes: KLK2 KLK3 PRKAR2A PRKCA PTPRF SEMG1 SERPINA5 TGM1	14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI
Entrez ID		6407	354
HPRD ID		01642	01461
Ensembl ID		ENSG00000124157	ENSG00000142515
Uniprot IDs		Q02383	P07288 Q546G3
PDB IDs			2ZCH 2ZCK 2ZCL 3QUM 9F1I
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein-containing Complex Zymogen Activation Regulation Of Systemic Arterial Blood Pressure Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Chondroitin Sulfate Proteoglycan Binding Serine-type Peptidase Activity Secretory Granule Platelet Dense Tubular Network Seminal Clot Liquefaction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Cell Envelope Organization Positive Regulation Of Antibacterial Peptide Production Acrosin Binding Protein Kinase C Signaling Negative Regulation Of Receptor Binding Insemination Serine-type Endopeptidase Activity Heparin Binding Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Blood Pressure Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extracellular Space Protein Processing Positive Regulation Of Antimicrobial Humoral Response CAMP-dependent Protein Kinase Regulator Activity Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein-glutamine Gamma-glutamyltransferase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endopeptidase Activity Regulation Of Antimicrobial Humoral Response Protein Metabolic Process	Extracellular Region Extracellular Space Protease Binding Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Blood Microparticle Extracellular Exosome Coagulation Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Acute-phase Response Endopeptidase Inhibitor Activity Acute Inflammatory Response Antibacterial Humoral Response Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Reproductive Process Endoplasmic Reticulum Lumen Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Sperm Capacitation Antimicrobial Humoral Response Regulation Of Cilium Movement Defense Response Biological Process Involved In Interaction With Symbiont Developmental Process Involved In Reproduction Growth Factor Binding Erythropoietin Receptor Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Regulation Of Microtubule-based Movement Regulation Of Cell Motility Humoral Immune Response Regulation Of Locomotion Negative Regulation Of Reproductive Process Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Seminal Clot Liquefaction
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