PKIB and DYNLL1

Number of citations of the paper that reports this interaction (PMID 11978406)
2

Data Source:
HPRD (in vivo, two hybrid)

		PKIB	DYNLL1
Gene Name		protein kinase (cAMP-dependent, catalytic) inhibitor beta	dynein, light chain, LC8-type 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity
	Biological Process	Negative Regulation Of CAMP-dependent Protein Kinase Activity	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways			Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: DYNLL1 E2F1 E2F3 LY6D PIN1 PRKACB	77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A
Entrez ID		5570	8655
HPRD ID		06075	03334
Ensembl ID		ENSG00000135549	ENSG00000088986
Uniprot IDs		Q9C010	P63167 Q6FGH9
PDB IDs			1CMI 3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Cell Cycle Regulation Of Mitochondrion Organization Response To Clozapine Regulation Of Establishment Of Protein Localization Notch Signaling Pathway Mitotic Cell Cycle Regulation Of Protein Localization Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Immune System Process Intrinsic Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Cycle Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Response To Organic Substance Anoikis Positive Regulation Of Cellular Metabolic Process Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Signal Transduction Signal Transduction Regulation Of Phosphorylation Apoptotic Signaling Pathway Response To Stilbenoid Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Activation Of Protein Kinase A Activity Negative Regulation Of Phosphorylation Cell Communication Positive Regulation Of Organelle Organization Regulation Of Phosphorus Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Transport Positive Regulation Of Metabolic Process Triglyceride Catabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Acylglycerol Catabolic Process MRNA Stabilization Negative Regulation Of Meiotic Cell Cycle Renal Water Homeostasis	Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process
Tagcloud ?		accessible bi537947 cows dairy ddit4 disodium downregulated edta experimentally fever hypocalcemia hypocalcemic incorporated infusion leukocytes microarray milk nesp55 neuroendocrine nuak nuak1 oligo parturient per1 secretory snf1 subtle tag verified	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		accessible bi537947 cows dairy ddit4 disodium downregulated edta experimentally fever hypocalcemia hypocalcemic incorporated infusion leukocytes microarray milk nesp55 neuroendocrine nuak nuak1 oligo parturient per1 secretory snf1 subtle tag verified	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Intersection) ?