PKIB and E2F3

Number of citations of the paper that reports this interaction (PMID 12748276)
36

Data Source:
BioGRID (two hybrid)

		PKIB	E2F3
Gene Name		protein kinase (cAMP-dependent, catalytic) inhibitor beta	E2F transcription factor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity	Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of CAMP-dependent Protein Kinase Activity	Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated
Pathways			Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase Cellular Senescence M/G1 Transition Regulation of DNA replication CDC6 association with the ORC:origin complex Oncogene Induced Senescence Cell Cycle, Mitotic Assembly of the pre-replicative complex Cyclin D associated events in G1 Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence G2 Phase Pre-NOTCH Expression and Processing Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Mitotic G1-G1/S phases
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: DYNLL1 E2F1 E2F3 LY6D PIN1 PRKACB	23 interactors: ATAD2 CCNA2 CDK3 CREBBP FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 WNK1 YY1
Entrez ID		5570	1871
HPRD ID		06075	02693
Ensembl ID		ENSG00000135549	ENSG00000112242
Uniprot IDs		Q9C010	O00716 Q24JQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Cell Cycle Regulation Of Mitochondrion Organization Response To Clozapine Regulation Of Establishment Of Protein Localization Notch Signaling Pathway Mitotic Cell Cycle Regulation Of Protein Localization Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Immune System Process Intrinsic Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Cycle Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Response To Organic Substance Anoikis Positive Regulation Of Cellular Metabolic Process Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Signal Transduction Signal Transduction Regulation Of Phosphorylation Apoptotic Signaling Pathway Response To Stilbenoid Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Activation Of Protein Kinase A Activity Negative Regulation Of Phosphorylation Cell Communication Positive Regulation Of Organelle Organization Regulation Of Phosphorus Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Transport Positive Regulation Of Metabolic Process Triglyceride Catabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Acylglycerol Catabolic Process MRNA Stabilization Negative Regulation Of Meiotic Cell Cycle Renal Water Homeostasis	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Positive Regulation Of Metabolic Process Mitotic Nuclear Division Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Cell Cycle DNA-templated Transcription, Initiation Mitotic Cell Cycle Process Regulation Of Cellular Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Cell Cycle Process Cell Division Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Enucleate Erythrocyte Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Transferase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle
Tagcloud ?		accessible bi537947 cows dairy ddit4 disodium downregulated edta experimentally fever hypocalcemia hypocalcemic incorporated infusion leukocytes microarray milk nesp55 neuroendocrine nuak nuak1 oligo parturient per1 secretory snf1 subtle tag verified	34a arrest carcinogenic chemokine concern concerned creates ct cytotoxicity doses frequent greatly involves ionizing killer mammographies medical micro mir mirna overexposure pathways patterns presentation radiation ray scans successfully workers
Tagcloud (Difference) ?		accessible bi537947 cows dairy ddit4 disodium downregulated edta experimentally fever hypocalcemia hypocalcemic incorporated infusion leukocytes microarray milk nesp55 neuroendocrine nuak nuak1 oligo parturient per1 secretory snf1 subtle tag verified	34a arrest carcinogenic chemokine concern concerned creates ct cytotoxicity doses frequent greatly involves ionizing killer mammographies medical micro mir mirna overexposure pathways patterns presentation radiation ray scans successfully workers
Tagcloud (Intersection) ?