PKIB and E2F3

Number of citations of the paper that reports this interaction (PubMedID 12748276)
56

Data Source:
BioGRID (two hybrid)

		PKIB	E2F3
Description		cAMP-dependent protein kinase inhibitor beta	E2F transcription factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Telomere Maintenance	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways			Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence G2 Phase Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) White blood cell count ( 32888494)	Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Estimated glomerular filtration rate in non-diabetics ( 31451708) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Obesity-related traits ( 23251661) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006)
Interacting Genes		9 interacting genes: DYNLL1 E2F1 E2F3 KRTAP3-1 LY6D NLGN3 PIN1 PRKACA PRKACB	26 interacting genes: ATAD2 CCNA2 CCNF CDK3 DNMT3L FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RCAN1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 UCHL5 WNK1 YY1
Entrez ID		5570	1871
HPRD ID		06075	02693
Ensembl ID		ENSG00000135549	ENSG00000112242
Uniprot IDs		Q9C010	O00716
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fat Cell Proliferation CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Activity High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis DNA-binding Transcription Activator Activity Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Multicellular Organismal-level Water Homeostasis Cellular Response To Fluid Shear Stress Negative Regulation Of Smoothened Signaling Pathway Centrosome Ciliary Base Response To Fluid Shear Stress Regulation Of Protein Processing Regulation Of Protein Maturation Cis-trans Isomerase Activity Negative Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Stress Multicellular Organismal-level Chemical Homeostasis Scaffold Protein Binding Regulation Of Biological Quality Negative Regulation Of Catabolic Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Smoothened Signaling Pathway TOR Signaling Positive Regulation Of Insulin Secretion Neural Tube Closure Negative Regulation Of TOR Signaling Tube Closure Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of TORC1 Signaling Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Renal System Process Lens Fiber Cell Apoptotic Process RNA Polymerase II Transcription Regulator Complex Tube Formation	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Chromatin Remodeling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Organization Rb-E2F Complex Transcription Regulator Complex Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex Binding Cell Cycle Phase Transition DNA Binding DNA-binding Transcription Factor Binding Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Ino80 Complex Regulation Of DNA Strand Elongation Response To Hormone Transcription Factor Binding Negative Regulation Of Calcium-mediated Signaling Regulation Of Chromosome Organization
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