FHL5 and HEY2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FHL5	HEY2
Description		four and a half LIM domains 5	hes related family bHLH transcription factor with YRPW motif 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Z Disc	Chromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cardiac Muscle Hypertrophy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Pattern Specification Process Heart Development Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Positive Regulation Of Heart Rate Regulation Of Gene Expression Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Smooth Muscle Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation By RNA Polymerase II Labyrinthine Layer Blood Vessel Development Blood Vessel Endothelial Cell Differentiation Artery Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Protein-DNA Complex Assembly Negative Regulation Of Biomineral Tissue Development Circulatory System Development Cochlea Development Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Cerebral blood flow ( 28627999) Cluster headache ( 34184781) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 27322543 27182965 23793025 22683712) Migraine - clinic-based ( 23793025) Migraine without aura ( 27322543 23793025) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 23872634 35210625 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Migraine ( 27322543) Night sleep phenotypes ( 27126917) Serum metabolite concentrations in chronic kidney disease ( 33838163) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172)
Interacting Genes		89 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A ATOSB BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FARS2 FEZF1 FHL2 GARIN6 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SAXO4 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1	27 interacting genes: ARNT ATXN1 CYSRT1 ENO1 FHL5 HAND1 HAND2 HDAC1 HES1 HOXA1 HSF2BP KRTAP1-1 KRTAP11-1 KRTAP3-1 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP8-1 NCOR1 PDLIM7 PLSCR1 RBPMS SIN3A SIRT1 TRAF1 TRAF4
Entrez ID		9457	23493
HPRD ID		05497	05243
Ensembl ID		ENSG00000112214	ENSG00000135547
Uniprot IDs		Q5TD97	Q5TF93 Q9UBP5
PDB IDs		1X68
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Nucleus Heart Trabecula Formation Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Zinc Ion Binding ATF4-CREB1 Transcription Factor Complex Regulation Of Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb	Intermediate Filament RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Androgen Receptor Signaling Pathway Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis HLH Domain Binding Cardiac Right Ventricle Formation Keratin Filament Chromatin Regulation Of Transcription By RNA Polymerase II Cytosol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Identical Protein Binding Histone Deacetylase Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cardiac Neural Crest Cell Development Involved In Heart Development Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Heart Left/right Asymmetry Transcription Corepressor Binding Cardiac Ventricle Formation Negative Regulation Of Transcription By RNA Polymerase II Cartilage Morphogenesis E-box Binding Regulation Of Cardioblast Proliferation Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gliogenesis Transcription Repressor Complex Artery Morphogenesis Cardiac Chamber Formation Protein Dimerization Activity Regulation Of Cellular Response To Growth Factor Stimulus DNA Binding Protein Deacetylation Protein Lysine Deacetylase Activity Odontogenesis Of Dentin-containing Tooth Embryonic Heart Tube Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of ATP Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process
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