FHL5 and LRRC41

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FHL5	LRRC41
Description		four and a half LIM domains 5	leucine rich repeat containing 41
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Z Disc	Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Protein Ubiquitination
Pathways			Neddylation RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cerebral blood flow ( 28627999) Cluster headache ( 34184781) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 27322543 27182965 23793025 22683712) Migraine - clinic-based ( 23793025) Migraine without aura ( 27322543 23793025) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)	Body mass index ( 26426971)
Interacting Genes		89 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A ATOSB BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FARS2 FEZF1 FHL2 GARIN6 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SAXO4 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1	11 interacting genes: CYSRT1 ELOB ELOC FHL5 KRT31 KRT34 KRTAP3-1 KRTAP6-2 MYO9B RBPMS UBC
Entrez ID		9457	10489
HPRD ID		05497	10102
Ensembl ID		ENSG00000112214	ENSG00000132128
Uniprot IDs		Q5TD97	Q15345
PDB IDs		1X68
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Nucleus Heart Trabecula Formation Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Zinc Ion Binding ATF4-CREB1 Transcription Factor Complex Regulation Of Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb	Intermediate Filament Target-directed MiRNA Degradation Elongin Complex Keratin Filament Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Epidermis Development MiRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Structural Molecule Activity Transcription Initiation At RNA Polymerase II Promoter Transcription Corepressor Binding Structural Constituent Of Skin Epidermis ARF Protein Signal Transduction Cytosol Intermediate Filament Organization DNA-templated Transcription Initiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process VCB Complex Ubiquitin Ligase Complex MRNA CDS Binding Roundabout Signaling Pathway Post-transcriptional Gene Silencing Roundabout Binding Lamellipodium Morphogenesis Protein Ubiquitination Postsynaptic Actin Cytoskeleton RNA Catabolic Process Pre-mRNA Intronic Binding Protein Modification By Small Protein Conjugation
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