FHL5 and CDC20B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FHL5	CDC20B
Description		four and a half LIM domains 5	cell division cycle 20B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Z Disc	Anaphase-promoting Complex Cytoplasm Deuterosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin Ligase Activator Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Anaphase-promoting Complex-dependent Catabolic Process De Novo Centriole Assembly Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways
Drugs
Diseases
GWAS		Cerebral blood flow ( 28627999) Cluster headache ( 34184781) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 27322543 27182965 23793025 22683712) Migraine - clinic-based ( 23793025) Migraine without aura ( 27322543 23793025) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)	Cocaine dependence ( 31212010)
Interacting Genes		89 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A ATOSB BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FARS2 FEZF1 FHL2 GARIN6 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SAXO4 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1	21 interacting genes: CCDC57 FHL5 GEMIN4 GOLGA2 KANK2 KRT31 KRT34 KRT40 MAGEA11 MDFI MTUS2 NUTM1 PLEKHF2 PLK2 SPAG5 TACC3 TRAF2 TRIM23 TRIM27 TRIM37 VPS52
Entrez ID		9457	166979
HPRD ID		05497	13428
Ensembl ID		ENSG00000112214	ENSG00000164287
Uniprot IDs		Q5TD97	Q86Y33
PDB IDs		1X68
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Nucleus Heart Trabecula Formation Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Zinc Ion Binding ATF4-CREB1 Transcription Factor Complex Regulation Of Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb	Spindle Organization Cytoskeleton Organization Spindle Pole Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Mitotic Spindle Organization Microtubule Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin-protein Transferase Activity Regulation Of Microtubule-based Process Establishment Of Localization In Cell Intracellular Transport Organelle Organization Regulation Of Cytoskeleton Organization Regulation Of Centriole Replication Microtubule Cytoskeleton Organization Involved In Mitosis Centriolar Satellite Mitotic Spindle Microtubule Nucleation Tumor Necrosis Factor Receptor Binding Ubiquitin Protein Ligase Activity Mitotic Cell Cycle Phase Transition Regulation Of Autophagy Intermediate Filament Cell Cycle Phase Transition Centrosome Positive Regulation Of Autophagy Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly Structural Molecule Activity Regulation Of Cell Cycle Cellular Localization Regulation Of Centrosome Duplication Regulation Of Cell Cycle Process Syntaxin Binding Microtubule-based Process Regulation Of Centrosome Cycle Regulation Of Organelle Organization TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Vitamin D Receptor Signaling Pathway Supramolecular Fiber Organization Spindle Microtubule Binding Protein Autoubiquitination Regulation Of Organelle Assembly
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