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PRKACA and PDPK1
Number of citations of the paper that reports this interaction (PubMedID
10698939
)
45
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, two hybrid)
PRKACA
PDPK1
Description
protein kinase cAMP-activated catalytic subunit alpha
3-phosphoinositide dependent protein kinase 1
Image
GO Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Centrosome
Cytosol
Plasma Membrane
Cilium
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nuclear Speck
Cytoplasmic Vesicle
Motile Cilium
Nucleotide-activated Protein Kinase Complex
Neuromuscular Junction
Calcium Channel Complex
Sperm Flagellum
Cell Projection
Plasma Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Sperm Midpiece
Ciliary Base
Postsynapse
Glutamatergic Synapse
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Cell Projection
Anchoring Junction
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Manganese Ion Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Regulatory Subunit Binding
Channel Activator Activity
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Phospholipase Binding
Protein Serine Kinase Activity
Biological Process
Mesoderm Formation
Neural Tube Closure
Regulation Of Heart Rate
Renal Water Homeostasis
MRNA Processing
Protein Phosphorylation
Protein Export From Nucleus
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Cytokine-mediated Signaling Pathway
Intracellular Potassium Ion Homeostasis
Cellular Response To Nutrient Levels
Positive Regulation Of Insulin Secretion
Negative Regulation Of Interleukin-2 Production
High-density Lipoprotein Particle Assembly
Cellular Response To Heat
Mitochondrial Protein Catabolic Process
Interleukin-2-mediated Signaling Pathway
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Regulation Of Osteoblast Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Protein Export From Nucleus
Sperm Capacitation
Positive Regulation Of Phagocytosis
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Calcium-mediated Signaling
Regulation Of Cell Cycle
Regulation Of Cardiac Muscle Contraction
Regulation Of Proteasomal Protein Catabolic Process
Cellular Response To Cold
Regulation Of Protein Processing
Cellular Response To Glucose Stimulus
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Glucagon Stimulus
Cellular Response To Epinephrine Stimulus
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Postsynaptic Modulation Of Chemical Synaptic Transmission
CAMP/PKA Signal Transduction
Regulation Of Cardiac Conduction
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Protein Localization To Lipid Droplet
Regulation Of Bicellular Tight Junction Assembly
Type B Pancreatic Cell Development
Protein Phosphorylation
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Mast Cell Degranulation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Intracellular Signaling Cassette
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Triglyceride catabolism
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of Adenylate Cyclase
Interleukin-3, Interleukin-5 and GM-CSF signaling
Ion homeostasis
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
RET signaling
AURKA Activation by TPX2
HDL assembly
ROBO receptors bind AKAP5
Loss of phosphorylation of MECP2 at T308
Regulation of MECP2 expression and activity
GPER1 signaling
GPER1 signaling
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
Mitochondrial protein degradation
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Pentanal
Balanol Analog 2
3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate
Phosphonothreonine
Balanol Analog 1
3,5-Diiodotyrosine
Balanol
Dexfosfoserine
S,S-(2-Hydroxyethyl)Thiocysteine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Ellagic acid
Fostamatinib
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
Bisindolylmaleimide VIII
Staurosporine
Bisindolylmaleimide I
Dexfosfoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Fostamatinib
Diseases
GWAS
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
207 interacting genes:
AANAT
ABCA1
ACLY
ADCY5
ADD1
ADD2
AKAP14
AKAP8L
AKIP1
ANXA7
APC
APOBEC3G
ARFGEF3
ASIC1
ASIC3
ATF1
ATG12
ATP2B1
AURKA
AVPI1
BAD
BCL2
BRAF
CACNA1C
CACNB2
CACNG2
CAD
CALD1
CAMKK2
CCDC88A
CCND1
CDK16
CDKN1A
CETN1
CFTR
CIITA
CLDN3
CLTC
CREB1
CREM
CRK
CSK
CUL5
CYP3A4
DMTN
DNAJC5
DOCK1
DRD1
DSP
EEF2K
EGFR
ERBB3
ESR1
ETV1
FBXW11
FOS
FXYD1
GABRB3
GABRR1
GAD1
GAD2
GFAP
GJA5
GJB1
GLI1
GMFB
GNA13
GNMT
GP1BB
GRIA1
GRIA4
GRK2
GSK3A
GSK3B
GUSB
GYS1
HAND1
HAND2
HDAC1
HDAC8
HIF1A
HMGCR
HMGN1
HMGN2
HNF4A
HNRNPD
HSPA4
HSPD1
IFNAR1
IQGAP1
IRF2
ITCH
ITGA2B
ITGA4
ITPKA
ITPKB
ITPR1
ITPR2
KCNH2
KCNJ12
KCNQ1
KDELR1
KLF1
KLHL3
LCK
LCP1
LIPE
LRP1
MAP2
MAP3K3
MAPT
MBP
MC4R
MEF2D
MEP1B
MGMT
MIP
NDRG1
NFKB1
NHERF2
NIN
NOLC1
NOS1
NOXA1
NR3C1
NSFL1C
NUP85
PARK7
PDC
PDE3A
PDE3B
PDE4B
PDE4D
PDPK1
PFKFB1
PFKFB2
PHKA1
PHOX2A
PKIA
PKIB
PLIN1
PLN
POU2F1
PPP1R10
PPP1R17
PPP1R1B
PPP1R8
PPP1R9B
PRKAR1A
PRKAR2A
PSEN1
PSMD11
PTBP1
PTPN12
PTPN13
PTPN7
PTPRR
RAF1
RANBP9
RAP1A
RAP1B
RAP1GAP
RASGRF1
RASGRP3
RELA
RGS10
RGS13
RGS14
RHOA
RRAD
RSBN1
RYR1
RYR2
SI
SIK1
SIK3
SLC2A2
SLC4A4
SNAP25
SNAPIN
SNPH
SOX9
SPTBN1
SRC
STK11
STMN1
STMN2
STUB1
SYN1
SYN2
TH
THOP1
TNP1
TNP2
TPH1
TPR
TRIM55
TRIM63
TRIP10
UBE3A
UHRF1
USP20
VASP
VIM
VTN
WT1
YWHAZ
68 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
CSNK1D
CUL3
DDIT4
GIT1
GSK3B
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
KLHL20
LUC7L2
MAPK8
MTOR
NHERF2
PAK1
PEA15
PHAX
PIK3C3
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SMARCB1
SOCS3
SPOP
SRC
SRPK1
STRAP
TCAP
UBC
UBE2I
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
Entrez ID
5566
5170
HPRD ID
03382
05556
Ensembl ID
ENSG00000072062
ENSG00000140992
Uniprot IDs
A0A8V8TL59
A8K8B9
P17612
E9PER6
O15530
PDB IDs
2GU8
3AGL
3AGM
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
4AE6
4AE9
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
5BX6
5BX7
5IZF
5IZJ
5J5X
5N23
5UZK
6BYR
6BYS
6C0U
6FRX
6NO7
6QJ7
6WJF
6WJG
7Y1G
8FE2
8FE5
8FEC
8X5L
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
6WJQ
8DQT
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Regulation Of Biological Quality
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Transport
Intracellular Signaling Cassette
Cellular Response To Oxygen-containing Compound
Cytosol
Cytoplasm
Regulation Of Protein Localization
Developmental Process
Signal Transduction
Protein Kinase A Catalytic Subunit Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
System Process
Regulation Of Membrane Potential
Calmodulin Binding
Regulation Of Multicellular Organismal Process
Regulation Of Cellular Localization
Scaffold Protein Binding
Response To Purine-containing Compound
Response To Metal Ion
Learning Or Memory
Cellular Developmental Process
Cell Development
Cellular Response To Growth Factor Stimulus
Regulation Of Blood Circulation
Response To Growth Factor
Learning
Signal Release
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Neuron Projection
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Localization
Regulation Of Heart Contraction
Cognition
Regulation Of G Protein-coupled Receptor Signaling Pathway
Protein Kinase Binding
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Associative Learning
Negative Regulation Of Signal Transduction
Enzyme Binding
Positive Regulation Of Multicellular Organismal Process
Response To Hormone
Response To Peptide Hormone
Biological_process
Protein Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Kinase Activity
Protein Phosphorylation
Phosphorylation
Intracellular Signal Transduction
ATP Binding
Protein Modification Process
Cytosol
Cellular Response To Peptide Hormone Stimulus
Nucleotide Binding
Cellular Response To Oxygen-containing Compound
Protein Metabolic Process
Cellular Response To Hormone Stimulus
Cytoplasm
Diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Cellular Response To Insulin Stimulus
Nucleus
TOR Signaling
Transferase Activity
TORC1 Signaling
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Response To Peptide Hormone
Negative Regulation Of Cellular Response To Insulin Stimulus
Response To Hormone
Phosphate-containing Compound Metabolic Process
Signal Transduction
Regulation Of Signal Transduction
Negative Regulation Of TOR Signaling
Regulation Of Generation Of Precursor Metabolites And Energy
Cellular Response To Insulin Stimulus
Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Regulation Of TOR Signaling
Regulation Of Signaling
Negative Regulation Of Apoptotic Process
Regulation Of Cell Communication
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Programmed Cell Death
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Signal Transduction
Cellular Response To Fluid Shear Stress
Regulation Of Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Signal Transduction
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