PRKACA and GP1BB

Number of citations of the paper that reports this interaction (PubMedID 2504723)
0

Data Source:
HPRD (in vitro)

		PRKACA	GP1BB
Description		protein kinase cAMP-activated catalytic subunit alpha	glycoprotein Ib platelet subunit beta
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Cytosol Plasma Membrane Cilium Axoneme CAMP-dependent Protein Kinase Complex Membrane Nuclear Speck Cytoplasmic Vesicle Motile Cilium Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Calcium Channel Complex Sperm Flagellum Cell Projection Plasma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Sperm Midpiece Ciliary Base Postsynapse Glutamatergic Synapse	Plasma Membrane Membrane Glycoprotein Ib-IX-V Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Domain Specific Binding Manganese Ion Binding Ubiquitin Protein Ligase Binding Protein Kinase A Regulatory Subunit Binding Channel Activator Activity Protein Serine Kinase Activity	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Mesoderm Formation Neural Tube Closure Regulation Of Heart Rate Renal Water Homeostasis MRNA Processing Protein Phosphorylation Protein Export From Nucleus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Potassium Ion Homeostasis Cellular Response To Nutrient Levels Positive Regulation Of Insulin Secretion Negative Regulation Of Interleukin-2 Production High-density Lipoprotein Particle Assembly Cellular Response To Heat Mitochondrial Protein Catabolic Process Interleukin-2-mediated Signaling Pathway TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Osteoblast Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Protein Export From Nucleus Sperm Capacitation Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Regulation Of Protein Processing Cellular Response To Glucose Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Epinephrine Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Postsynaptic Modulation Of Chemical Synaptic Transmission CAMP/PKA Signal Transduction Regulation Of Cardiac Conduction Negative Regulation Of TORC1 Signaling Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Regulation Of Bicellular Tight Junction Assembly	Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Interleukin-3, Interleukin-5 and GM-CSF signaling Ion homeostasis Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Anchoring of the basal body to the plasma membrane CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling AURKA Activation by TPX2 HDL assembly ROBO receptors bind AKAP5 Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production Mitochondrial protein degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		Pentanal Balanol Analog 2 3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate Phosphonothreonine Balanol Analog 1 3,5-Diiodotyrosine Balanol Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine Hydroxyfasudil (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine (2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE H-89 5-(2-methylpiperazine-1-sulfonyl)isoquinoline N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE 3-pyridin-4-yl-1H-indazole 5-benzyl-1,3-thiazol-2-amine 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium Fasudil Myristic acid A-674563 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE Y-27632 Ellagic acid Fostamatinib
Diseases			Bernard-Soulier syndrome; Giant platelet syndrome
GWAS			DNA methylation (parent-of-origin) ( 23725790) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		207 interacting genes: AANAT ABCA1 ACLY ADCY5 ADD1 ADD2 AKAP14 AKAP8L AKIP1 ANXA7 APC APOBEC3G ARFGEF3 ASIC1 ASIC3 ATF1 ATG12 ATP2B1 AURKA AVPI1 BAD BCL2 BRAF CACNA1C CACNB2 CACNG2 CAD CALD1 CAMKK2 CCDC88A CCND1 CDK16 CDKN1A CETN1 CFTR CIITA CLDN3 CLTC CREB1 CREM CRK CSK CUL5 CYP3A4 DMTN DNAJC5 DOCK1 DRD1 DSP EEF2K EGFR ERBB3 ESR1 ETV1 FBXW11 FOS FXYD1 GABRB3 GABRR1 GAD1 GAD2 GFAP GJA5 GJB1 GLI1 GMFB GNA13 GNMT GP1BB GRIA1 GRIA4 GRK2 GSK3A GSK3B GUSB GYS1 HAND1 HAND2 HDAC1 HDAC8 HIF1A HMGCR HMGN1 HMGN2 HNF4A HNRNPD HSPA4 HSPD1 IFNAR1 IQGAP1 IRF2 ITCH ITGA2B ITGA4 ITPKA ITPKB ITPR1 ITPR2 KCNH2 KCNJ12 KCNQ1 KDELR1 KLF1 KLHL3 LCK LCP1 LIPE LRP1 MAP2 MAP3K3 MAPT MBP MC4R MEF2D MEP1B MGMT MIP NDRG1 NFKB1 NHERF2 NIN NOLC1 NOS1 NOXA1 NR3C1 NSFL1C NUP85 PARK7 PDC PDE3A PDE3B PDE4B PDE4D PDPK1 PFKFB1 PFKFB2 PHKA1 PHOX2A PKIA PKIB PLIN1 PLN POU2F1 PPP1R10 PPP1R17 PPP1R1B PPP1R8 PPP1R9B PRKAR1A PRKAR2A PSEN1 PSMD11 PTBP1 PTPN12 PTPN13 PTPN7 PTPRR RAF1 RANBP9 RAP1A RAP1B RAP1GAP RASGRF1 RASGRP3 RELA RGS10 RGS13 RGS14 RHOA RRAD RSBN1 RYR1 RYR2 SI SIK1 SIK3 SLC2A2 SLC4A4 SNAP25 SNAPIN SNPH SOX9 SPTBN1 SRC STK11 STMN1 STMN2 STUB1 SYN1 SYN2 TH THOP1 TNP1 TNP2 TPH1 TPR TRIM55 TRIM63 TRIP10 UBE3A UHRF1 USP20 VASP VIM VTN WT1 YWHAZ	4 interacting genes: GP9 PRKACA TGFB1I1 YWHAZ
Entrez ID		5566	2812
HPRD ID		03382	00729
Ensembl ID		ENSG00000072062	ENSG00000203618
Uniprot IDs		A0A8V8TL59 A8K8B9 P17612	P13224
PDB IDs		2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9 4UJ1 4UJ2 4UJ9 4UJA 4UJB 4WB5 4WB6 4WB7 4WB8 5BX6 5BX7 5IZF 5IZJ 5J5X 5N23 5UZK 6BYR 6BYS 6C0U 6FRX 6NO7 6QJ7 6WJF 6WJG 7Y1G 8FE2 8FE5 8FEC 8X5L	3REZ 3RFE 8WFS
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transport Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Cytosol Cytoplasm Regulation Of Protein Localization Developmental Process Signal Transduction Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane System Process Regulation Of Membrane Potential Calmodulin Binding Regulation Of Multicellular Organismal Process Regulation Of Cellular Localization Scaffold Protein Binding Response To Purine-containing Compound Response To Metal Ion Learning Or Memory Cellular Developmental Process Cell Development Cellular Response To Growth Factor Stimulus Regulation Of Blood Circulation Response To Growth Factor Learning Signal Release Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Neuron Projection Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Regulation Of Heart Contraction Cognition Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Kinase Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Associative Learning Negative Regulation Of Signal Transduction Enzyme Binding Positive Regulation Of Multicellular Organismal Process Response To Hormone Response To Peptide Hormone Biological_process	Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Sequestering Of Calcium Ion Tube Formation Synaptic Target Recognition Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Cell Communication Inner Ear Receptor Cell Differentiation Regulation Of Signal Transduction Mechanoreceptor Differentiation Positive Regulation Of Immune Response To Tumor Cell Cellular Developmental Process Pyroptotic Cell Death Wide Pore Channel Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Epithelial Cell Differentiation Regulation Of Signaling Developmental Process System Process Protein Activation Cascade Glycoprotein Ib-IX-V Complex Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Megakaryocyte Development Regulation Of Body Fluid Levels CAMP-dependent Protein Kinase Complex Protein-lipid Complex Assembly Vascular Endothelial Cell Response To Fluid Shear Stress Response To Nutrient Levels Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Glucagon Stimulus Ubiquitin Protein Ligase Binding Negative Regulation Of Interleukin-2 Production Response To Laminar Fluid Shear Stress Sperm Capacitation Protein Domain Specific Binding CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Protein Phosphorylation Calcium Channel Complex Regulation Of Proteolysis Cellular Response To Laminar Fluid Shear Stress
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