PRKACA and CYP3A4

Number of citations of the paper that reports this interaction (PMID 22101235)
5

Data Source:
BioGRID (enzymatic study)

		PRKACA	CYP3A4
Gene Name		protein kinase, cAMP-dependent, catalytic, alpha	cytochrome P450, family 3, subfamily A, polypeptide 4
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Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Motile Cilium AMP-activated Protein Kinase Complex Neuromuscular Junction Calcium Channel Complex Extracellular Vesicular Exosome Sperm Midpiece Ciliary Base	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	CAMP-dependent Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Regulatory Subunit Binding	Monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Taurochenodeoxycholate 6alpha-hydroxylase Activity Caffeine Oxidase Activity Albendazole Monooxygenase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity Vitamin D 24-hydroxylase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mesoderm Formation Neural Tube Closure Regulation Of Heart Rate Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Organelle Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Protein Binding Small Molecule Metabolic Process Innate Immune Response Regulation Of Osteoblast Differentiation Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway Sperm Capacitation Regulation Of Insulin Secretion Regulation Of Synaptic Transmission Cytosolic Calcium Ion Homeostasis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Processing Positive Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Epinephrine Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Tight Junction Assembly	Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Oxidation-reduction Process Oxidative Demethylation
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Recruitment of mitotic centrosome proteins and complexes Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Factors involved in megakaryocyte development and platelet production Aquaporin-mediated transport CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Signaling by Interleukins Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer Metabolism of carbohydrates PKA activation Interleukin-3, 5 and GM-CSF signaling Mitotic G2-G2/M phases Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance G2/M Transition VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Loss of Nlp from mitotic centrosomes Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Cytokine Signaling in Immune system Assembly of the primary cilium Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Signaling by FGFR Loss of proteins required for interphase microtubule organizationÂ from the centrosome PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome Centrosome maturation GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Aflatoxin activation and detoxification Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Xenobiotics Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS			Metabolic traits ( 21886157)
Protein-Protein Interactions		181 interactors: AANAT ABCA1 ACLY ADCY5 ADD1 ADD2 ADRBK1 AKAP13 AKAP14 AKAP8L AKIP1 ANXA7 APC APOBEC3G ASIC1 ASIC3 ATF1 ATP2B1 AURKA BAD BCL2 BRAF CACNA1C CACNB2 CACNG2 CAD CALD1 CAMKK2 CCDC88A CCND1 CDK16 CETN1 CFTR CIITA CLDN3 CLTC CREB1 CREM CSK CUL5 CYP3A4 DMTN DNAJC5 DSP EEF2K EGFR ESR1 ETV1 FOS FXYD1 GABRB3 GABRR1 GAD1 GAD2 GFAP GJA5 GJB1 GMFB GNA13 GNMT GP1BB GRIA1 GRIA4 GSK3A GSK3B GUSB GYS1 HAND1 HAND2 HDAC1 HDAC8 HMGCR HMGN1 HMGN2 HNRNPD HSPD1 IFNAR1 IQGAP1 IRF2 ITCH ITGA2B ITGA4 ITPKA ITPKB ITPR1 ITPR2 KCNH2 KCNJ12 KCNQ1 KLF1 LCK LCP1 LIPE LRP1 MAP2 MAP3K3 MAPT MBP MC4R MEF2D MEP1B MGMT MIP NDRG1 NFKB1 NIN NOLC1 NOS1 NOXA1 NR3C1 NUP85 PARK2 PDC PDE3B PDE4B PDE4D PDPK1 PFKFB1 PFKFB2 PHKA1 PHOX2A PKIA PLIN1 PLN POU2F1 PPP1R10 PPP1R17 PPP1R1B PPP1R8 PPP1R9B PRKAR1A PSEN1 PTBP1 PTPN12 PTPN13 PTPN7 PTPRR RAF1 RANBP9 RAP1A RAP1B RAP1GAP RASGRF1 RASGRP3 RELA RGS10 RGS13 RGS14 RHOA RRAD RSBN1 RYR1 RYR2 SI SIK1 SIK3 SLC2A2 SLC4A4 SLC9A3R2 SNAP25 SNAPIN SPTBN1 SRC STK11 STMN1 STMN2 SYN1 SYN2 TBXA2R TCF3 TH THOP1 TNP1 TNP2 TPH1 TRIP10 UHRF1 VASP VIM VTN WT1	9 interactors: AMFR CYB5A GK POR PRKACA PRKCA STUB1 UBC UGT2B7
Entrez ID		5566	1576
HPRD ID		03382	00484
Ensembl ID		ENSG00000072062
Uniprot IDs		P17612	P08684 Q6GRK0
PDB IDs		2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9	1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Anatomical Structure Development System Development Multicellular Organismal Development Developmental Process Response To Organonitrogen Compound Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Cell Differentiation Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Process Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cellular Localization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Response To Organic Cyclic Compound Energy Reserve Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Signaling Cellular Response To Growth Factor Stimulus Cell Development Regulation Of Phosphorus Metabolic Process Response To Abiotic Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Response To Metal Ion Positive Regulation Of Catalytic Activity Cellular Process Regulation Of Phosphorylation Organ Development Neurogenesis ERBB Signaling Pathway Response To Purine-containing Compound Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Body Fluid Levels Cell-cell Signaling Synaptic Transmission Response To Stress Response To Drug	Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Cellular Response To Organic Substance Monosaccharide Metabolic Process Small Molecule Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Organic Substance Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Catabolic Process Energy Reserve Metabolic Process Carbohydrate Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Polyubiquitination Negative Regulation Of Adenylate Cyclase Activity Flavonoid Metabolic Process Negative Regulation Of Lyase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Rhodopsin Mediated Signaling Pathway Response To Growth Factor Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Neurotrophin TRK Receptor Signaling Pathway Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Neurotrophin Signaling Pathway Inactivation Of MAPK Activity Regulation Of Hormone Metabolic Process Regulation Of Proteolysis Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		abrogated advance amplified bad bcl conferred discovered doi emergence frame her2 inactivated june lapatinib onc oncogene online permitting phosphoinositide pim1 publication reading rescue rescued restored sensitized trastuzumab uncover xl	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Difference) ?		abrogated advance amplified bad bcl conferred discovered doi emergence frame her2 inactivated june lapatinib onc oncogene online permitting phosphoinositide pim1 publication reading rescue rescued restored sensitized trastuzumab uncover xl	amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cyp2c19 cyp2c9 cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin
Tagcloud (Intersection) ?