LYAR and ZHX1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		LYAR	ZHX1
Description		Ly1 antibody reactive	zinc fingers and homeoboxes 1
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Nucleoplasm Nucleolus Cytoplasm Cell Projection	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process RRNA Processing Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Erythrocyte Development Positive Regulation Of Phagocytosis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration ( 29346644)
Interacting Genes		16 interacting genes: ADSS1 BEND7 CD2 FGF18 GSK3B OGT PDE4B PHF20L1 PRKRA SDCBP2 SNRPA SREK1IP1 TERF1 TERF2 ZBTB16 ZHX1	54 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZBED1 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX
Entrez ID		55646	11244
HPRD ID		10064	10379
Ensembl ID		ENSG00000145220	ENSG00000165156
Uniprot IDs		Q9NX58	Q9UKY1
PDB IDs		6ZMI 6ZMO 6ZVH	2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Shelterin Complex Telomerase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly NSL Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Telomere Capping Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Catabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Telomeric DNA Binding Protein Homodimerization Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Cartilage Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Identical Protein Binding Nucleoplasm Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Metabolic Process Male Germ Cell Nucleus Regulation Of Chondrocyte Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Metabolic Process Superior Temporal Gyrus Development	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly RNA Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Response To Radiation Regulation Of Release Of Cytochrome C From Mitochondria RNA Binding Positive Regulation Of Metabolic Process Protein Tag Activity Cellular Response To Stress Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Apoptotic Signaling Pathway DNA Damage Response Regulation Of Mitochondrial Membrane Permeability RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Transferase Activity Protein Binding Regulation Of Cellular Response To Stress
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