LYAR and FGF18

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LYAR	FGF18
Gene Name		Ly1 antibody reactive	fibroblast growth factor 18
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Extracellular Region Extracellular Space Nucleolus
	Molecular Function	Protein Binding Poly(A) RNA Binding Metal Ion Binding	Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process		Angiogenesis Regulation Of Endothelial Cell Proliferation Intramembranous Ossification Endochondral Ossification Chondrocyte Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Lung Development Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways			Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ADSSL1 BEND7 CD2 FGF18 PHF20L1 PRKRA SDCBP2 TERF1 TERF2 ZBTB16 ZHX1	5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 LYAR
Entrez ID		55646	8817
HPRD ID		10064	04766
Ensembl ID		ENSG00000145220	ENSG00000156427
Uniprot IDs		Q9NX58	O76093
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Positive Regulation Of Chondrocyte Differentiation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cartilage Development Negative Regulation Of DNA Replication Regulation Of Chondrocyte Differentiation Cell Aging Telomere Maintenance Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Chromosome Organization Regulation Of Cartilage Development Immune System Process Negative Regulation Of DNA Metabolic Process Developmental Process Regulation Of T Cell Differentiation Skeletal System Development Regulation Of DNA Replication Negative Regulation Of Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Membrane Raft Polarization 'de Novo' AMP Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Interferon-gamma Secretion Protection From Non-homologous End Joining At Telomere Regulation Of Lymphocyte Differentiation Membrane Raft Localization Telomere Capping Positive Regulation Of NK T Cell Differentiation Protein Localization To Chromosome, Telomeric Region AMP Biosynthetic Process Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Myeloid Dendritic Cell Activation Cartilage Development Nucleobase-containing Compound Metabolic Process Aspartate Metabolic Process Regulation Of Chromosome Organization Heterocycle Metabolic Process	Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Lung Development Respiratory Tube Development Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Respiratory System Development Cell Fate Commitment Response To Insulin Cellular Response To Peptide Hormone Stimulus Lung Alveolus Development Cellular Response To Peptide Ventricular Zone Neuroblast Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Orbitofrontal Cortex Development Positive Regulation Of Phospholipase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Midbrain Development Regulation Of Phospholipase Activity Response To Peptide Positive Regulation Of Lipase Activity Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tube Development Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Lung Saccule Development Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound
Tagcloud ?		34a abcf2 adhesions alg13 bioinformatics chance ctcf fak held kaplan ki67 meier michigan mir nbl neuroblastoma originates proteome proteomics searches seed sh shep sy5y sympathetic tetracycline tgm2 timm13 utr	abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf10 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Difference) ?		34a abcf2 adhesions alg13 bioinformatics chance ctcf fak held kaplan ki67 meier michigan mir nbl neuroblastoma originates proteome proteomics searches seed sh shep sy5y sympathetic tetracycline tgm2 timm13 utr	abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf10 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Intersection) ?