GNPNAT1

Gene Name		glucosamine-phosphate N-acetyltransferase 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Late Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Endosome Membrane
	Molecular Function	Glucosamine 6-phosphate N-acetyltransferase Activity Monosaccharide Binding
	Biological Process	Liver Development Glucosamine Metabolic Process N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Synthesis of UDP-N-acetyl-glucosamine Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-protein Interactions		2 interactors: C1QA NAGK
Entrez ID		64841
HPRD ID		17046
Ensembl ID		ENSG00000100522
Uniprot IDs		Q96EK6
PDB IDs		2HUZ 2O28 3CXP 3CXQ 3CXS
Enriched GO Terms of Interacting Partners?		N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process N-acetylneuraminate Metabolic Process N-acetylglucosamine Metabolic Process Amino Sugar Metabolic Process Carbohydrate Phosphorylation
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