GNPNAT1 and PSMB8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNPNAT1	PSMB8
Description		glucosamine-phosphate N-acetyltransferase 1	proteasome 20S subunit beta 8
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Late Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endosome Membrane Membrane	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex
	Molecular Function	Glucosamine 6-phosphate N-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Identical Protein Binding	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	UDP-N-acetylglucosamine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Immune System Process Proteolysis Antigen Processing And Presentation Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Proteolysis Involved In Protein Catabolic Process
Pathways		Synthesis of UDP-N-acetyl-glucosamine	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Interferon alpha/beta signaling Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs			Carfilzomib
Diseases
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) IgA nephropathy ( 25305756 32912934) Nephropathy ( 21399633)
Interacting Genes		3 interacting genes: C1QA NAGK PSMB8	22 interacting genes: ABCB1 DUSP23 GNPNAT1 INCA1 LSM1 MEOX2 NFKBID PFDN5 POLR2G POMP PSMB10 REL SNX5 TAP1 TAP2 TENT5B TRAF3 TRIP13 UBAP2 WWOX YJEFN3 ZMYND12
Entrez ID		64841	5696
HPRD ID		17046	01515
Ensembl ID		ENSG00000100522	ENSG00000204264
Uniprot IDs		Q96EK6	P28062
PDB IDs		2HUZ 2O28 3CXP 3CXQ 3CXS	5L5A 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5LTT 5M2B 6AVO 6E5B 7AWE 7B12
Enriched GO Terms of Interacting Partners?		Complement Component C1q Complex IgM Binding Complement Component C1 Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Spermatoproteasome Complex N-acetylglucosamine Kinase Activity N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process N-acetylglucosamine Catabolic Process Muramyl Dipeptide Kinase Activity Extrinsic Component Of Postsynaptic Membrane Activation Of Immune Response Immune System Process Synapse Pruning Threonine-type Endopeptidase Activity UDP-N-acetylglucosamine Biosynthetic Process Protein Linear Polyubiquitination Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Catabolic Process Neuron Remodeling IgG Binding Proteasome Core Complex, Beta-subunit Complex UDP-N-acetylglucosamine Metabolic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway N-acetylglucosamine Metabolic Process Symbiont Cell Surface Astrocyte Activation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome Core Complex Carbohydrate Phosphorylation Response To Muramyl Dipeptide Innate Immune Response Positive Regulation Of Immune Response P38MAPK Cascade Nucleotide-sugar Biosynthetic Process Neuron Maturation Microglial Cell Activation Defense Response To Symbiont Leukocyte Activation Involved In Inflammatory Response Defense Response To Other Organism Complement Activation, Classical Pathway Amino Sugar Metabolic Process Nucleotide-sugar Metabolic Process Regulation Of Immune Response Complement Activation Positive Regulation Of Immune System Process	Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex ABC-type Peptide Transporter Activity TAP1 Binding Cytosol To Endoplasmic Reticulum Transport ABC-type Transporter Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I RNA Polymerase III Assembly RNA Polymerase I Assembly Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Amide Transport Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Antigen Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Macropinocytic Cup Glucosamine 6-phosphate N-acetyltransferase Activity ATP Hydrolysis Activity
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