GNPNAT1 and C1QA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GNPNAT1	C1QA
Description		glucosamine-phosphate N-acetyltransferase 1	complement C1q A chain
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Late Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endosome Membrane Membrane	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface
	Molecular Function	Glucosamine 6-phosphate N-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Identical Protein Binding	Amyloid-beta Binding Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	UDP-N-acetylglucosamine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Microglial Cell Activation Immune System Process Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Neuron Remodeling Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Inflammatory biomarkers (multivariate analysis) ( 33110245)
Interacting Genes		3 interacting genes: C1QA NAGK PSMB8	31 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HMGB1 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 TXN UBQLN1 UBQLN2 USP40
Entrez ID		64841	712
HPRD ID		17046	00393
Ensembl ID		ENSG00000100522	ENSG00000173372
Uniprot IDs		Q96EK6	P02745
PDB IDs		2HUZ 2O28 3CXP 3CXQ 3CXS	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
Enriched GO Terms of Interacting Partners?		Complement Component C1q Complex IgM Binding Complement Component C1 Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Spermatoproteasome Complex N-acetylglucosamine Kinase Activity N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process N-acetylglucosamine Catabolic Process Muramyl Dipeptide Kinase Activity Extrinsic Component Of Postsynaptic Membrane Activation Of Immune Response Immune System Process Synapse Pruning Threonine-type Endopeptidase Activity UDP-N-acetylglucosamine Biosynthetic Process Protein Linear Polyubiquitination Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Catabolic Process Neuron Remodeling IgG Binding Proteasome Core Complex, Beta-subunit Complex UDP-N-acetylglucosamine Metabolic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway N-acetylglucosamine Metabolic Process Symbiont Cell Surface Astrocyte Activation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome Core Complex Carbohydrate Phosphorylation Response To Muramyl Dipeptide Innate Immune Response Positive Regulation Of Immune Response P38MAPK Cascade Nucleotide-sugar Biosynthetic Process Neuron Maturation Microglial Cell Activation Defense Response To Symbiont Leukocyte Activation Involved In Inflammatory Response Defense Response To Other Organism Complement Activation, Classical Pathway Amino Sugar Metabolic Process Nucleotide-sugar Metabolic Process Regulation Of Immune Response Complement Activation Positive Regulation Of Immune System Process	Complement Component C1q Complex Binding Complement Activation, Classical Pathway Complement Component C1 Complex Complement Activation Blood Microparticle Cell Surface Opsonization Immune Effector Process Positive Regulation Of ERAD Pathway Symbiont Cell Surface Defense Response To Symbiont Defense Response To Other Organism Regulation Of ERAD Pathway Innate Immune Response Regulation Of Protein Metabolic Process Extracellular Region Response To Stress Humoral Immune Response Virion Binding Activation Of Immune Response Extracellular Matrix Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To External Biotic Stimulus Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Defense Response Response To Other Organism Negative Regulation By Host Of Viral Glycoprotein Metabolic Process TRC Complex Regulation Of Immune Response Immune Response Extracellular Space Identical Protein Binding Negative Regulation Of Endothelial Cell Migration Complement Component C1q Complex Positive Regulation Of Immune System Process Protein Targeting To ER Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Multicellular Organismal Development Establishment Of Protein Localization To Endoplasmic Reticulum IgM Binding Positive Regulation Of Proteolysis Negative Regulation Of Immune System Process Polyubiquitin Modification-dependent Protein Binding Acute-phase Response Positive Regulation Of Proteasomal Protein Catabolic Process Postsynapse
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