MCM10 and VPRBP

Number of citations of the paper that reports this interaction (PMID 22570418)
6

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		MCM10	VPRBP
Gene Name		minichromosome maintenance complex component 10	Vpr (HIV-1) binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleolus Cytoplasm COP9 Signalosome
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding ATP Binding Histone Kinase Activity (H2A-T120 Specific)
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation
Pathways		G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex Cell Cycle, Mitotic G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 TRIM37 VPRBP ZBTB43 ZBTB8A	14 interactors: ATM ATR HDAC1 HIST1H3A HIST3H3 KATNA1 MCM10 NF2 PRKDC RAG1 RBX1 TP53 UBE2D2 UNG
Entrez ID		55388	9730
HPRD ID		11297	11674
Ensembl ID		ENSG00000065328
Uniprot IDs		Q7L590	Q9Y4B6
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process DNA Replication Initiation DNA-dependent DNA Replication DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Unwinding Involved In DNA Replication Cellular Nitrogen Compound Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Cell Division Biosynthetic Process DNA Conformation Change Double-strand Break Repair Via Break-induced Replication Nitrogen Compound Metabolic Process Organelle Organization Chromosome Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Phosphorylation	DNA Metabolic Process Response To Gamma Radiation Replicative Senescence DNA Recombination B Cell Differentiation V(D)J Recombination DNA Repair Chromosome Organization Response To Ionizing Radiation Organelle Organization DNA Damage Checkpoint Double-strand Break Repair B Cell Activation Regulation Of Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Negative Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Pre-B Cell Allelic Exclusion Cell Cycle Cellular Response To DNA Damage Stimulus Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint B Cell Lineage Commitment Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint T Cell Differentiation In Thymus Cell Aging Lymphocyte Differentiation Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Cellular Response To Stress Pre-B Cell Differentiation Somitogenesis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Immature B Cell Differentiation Response To Hypoxia
Tagcloud ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	a3g accessory antiviral apobec3g computer crosstalk degradation disarmed downregulated encapsidation encountered existence highlight hiv hostile immunoprecipitation implicates intervene ligase observation proteasomal replication restricting screen unveiling versatility vif virion
Tagcloud (Difference) ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 rough surprisingly	a3g accessory antiviral apobec3g computer crosstalk degradation disarmed downregulated encapsidation encountered existence highlight hiv hostile immunoprecipitation implicates intervene ligase observation proteasomal restricting screen unveiling versatility vif virion
Tagcloud (Intersection) ?		replication